Carbohydrate-mediated cell adhesion is now widely recognised as being important in tissue injury and infection and is almost certainly involved in tumour cell adhesion and metastasis.  The Sialyl Lexisx tetrasaccharide was the first ligand identified in these processes (Philips et al (1990) Science 250:1132; Lowe et al (1990) Cell 63:475).  Sialyl Lewisa has a similar affinity for E,L and P selectins.

More recently the sulpahted forms of the Lewisa and Lewisx trisaccharides have been shown to exhibit high affinity binding to E-selectin (Yuen et al (1992) Biochemistry 31:9126; Green et al (1992) Biochem. Biophys. Res. Commun. 188:244).

We now offer these oligosaccharides and a range of neoglycoconjugates.

To permit studies of the effect of multivalency on binding affinity, we have coupled Sialyl Lewisa and Sialyl Lewisx to both Bovine Serum Albumin and Human Serum Albumin.  In addition, we also offer a conjugate of the Sialyl Lewisx analogue 3'-Sialyl-3-fucosyl lactose which has been shown to bind effectively to E-selectin (Tyrell et al (1991) Proc. Nat. Acad. Sci. USA 88:10372).