Special Offer | Drug Delivery

Drug Delivery Peptides - Special Offer 20% off*

*Valid through Mar 31, 2007. Please refer to order code MTJFM for getting the discount.

Introduction

Efficient transfer of proteins or nucleic acids across cellular membranes is one of the major problems in cell biology. To deliver the functional domain of a selected protein from the outside to the inside of intact cells, a carrier is needed. Cell Permeable Peptides, also known as Protein Transduction Domains (PTDs), are carriers with small peptide domains that can freely cross cell membranes. Several PTDs have been identified that allow a fused protein to efficiently cross cell membranes in a process known as protein transduction. Studies have demonstrated that a TAT peptide derived from the HIV TAT protein has the ability to transduce peptides or proteins into various cells. PTDs have been utilized in anticancer strategy, for example, a cell permeable Bcl-2 binding peptide, cpm1285, shows activity in slowing human myeloid leukemia growth in mice. Cell-permeable phosphopeptides, such as FGFR730pY, which mimics receptor binding sites for specific SH2 domain-containing proteins are potential tools for cancer research and cell signaling mechanism studies.

References

Embury, J. et al. Diabetes 50, 1706 (2001), Wang, H. et al. J. Clin. Invest. 109, 1463 (2002); Lin, Y-Z. J. Biol. Chem. 270, 14255 (1995); Holzberg, D. et al. J. Biol. Chem. 278, 40213 (2003); Williams, E. et al. J. Biol. Chem. 272, 22349 (1997); Nakatani, KH. et al. Nat. Med. 10, 1128 (2004); Mortlock, A. et al. Nucleic Acids Res. 31, e152 (2003); Kaneto, H. et al. Nat. Med. 10, 1128 (2004); Wang, JL. et al. Cancer Res. 60, 1498 (2000); Oess S. and E. Hildt, Gene. Ther. 7, 750 (2000); Dunican, D. et al. Cell Growth Diff. 12, 255 (2001).

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