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Cell Biology and Antibodies
Monoclonal antibodies against human cathepsins and cystatins
Antibodies for Cancer Research
Monoclonal antibodies against human cathepsins and cystatin A
Cathepsin L is a member of the papain family of closely related cysteine proteinases and it seems to be involved in a variety of disorders in which the pathological destruction of the extracellular matrix is one of the main characteristics. The numbering of the amino acids of the recognized epitopes is according to that of the human procathepsin L sequence. The sequences of the mature single and two chain enzymes are beginning at amino acid 97 of the procathepsin L sequence. The heavy chain (24 kDa) of mature two chain cathepsin L comprises amino acids 97 to 271, the light chain (4 kDa) those of amino acids 275 to 316.
Cathepsin W (lymphopain) is a recently described cysteine proteinase which is predominantly expressed by CD8+ -T-lymphocytes and natural killer cells. Due to sequence similarities between the propeptides of cathepsin W and cathepsin F, both enzymes may form a new cathepsin subgroup. Cystatin A (acid cysteine proteinase inhibitor, ACPI; Stefin A) is a natural inhibitor of cysteine proteinases. It seems to be important in the regulation of the intra- and the extracellular proteolytic potential of many cells and was recently shown to be involved in controlling apoptosis.
| Detection of purified mouse procathepsin L. |
| LIST OF ANTIBODIES: ORDER INFORMATION, SHIPPING AND STORAGE | ||||
| order # | product | clone | host | amount |
| 3012LS | Anti-human Cathepsin B | CB59-4B11 | mouse | 200 µg |
| 3001LS | Anti-human Cathepsin L / Procathepsin L | CPLH 33/1 | mouse | 100 µg |
| 3003LS | Anti-human Cathepsin L / Procathepsin L | CLP 1/36 | mouse | 200 µg |
| 3002LS | Anti-human Cathepsin L / Procathepsin L | CPLH 33/2 | mouse | 100 µg |
| 3013LS | Anti-human Cathepsin V | CV 55-1C5 | mouse | 200 µg |
| 3009LS | Anti-human Cystatin A | WR 23/2/3/3 | mouse | 200 µg |
| 3011LS | Anti-human Cystatin B | RJMW 2E7 | mouse | 200 µg |
| 3010LS | Anti-human Cystatin B | RJMW 4A10 | mouse | 200 µg |
| 3004LS | Anti-human Procathepsin L | CPLH 2D4 | mouse | 200 µg |
| 3006LS | Anti-human Procathepsin W | CW-40 1B1 | mouse | 200 µg |
| 3005LS | Anti-mouse Cathepsin L / Procathepsin L | CPLH 3G10 | mouse | 200 µg |
| concentration: 1 µg/µl; shipped on blue ice; store at 4°C | ||||
Polyclonal Antibodies for Cancer Research, Tumor Suppression, Cell Cycle
| LIST OF ANTIBODIES: ORDER INFORMATION, SHIPPING AND STORAGE | ||||
| order # | product | applic.* | description | amount |
| 24275SB | Anti-AXUD1 | WB, IHC | AXUD1 has a tumor-suppressor function e.g. in lung, placenta, pancreas | 100 µg |
| 24192SB | Anti-BRAF35 | WB, IHC | BRCA2-associated factor 35, plays a role in cell cycle progression and cancer | 100 µg |
| 24123 SB | Anti-Cyclin E1 | WB, IHC | Cyclin E2 level is elevated in human tumor cells | 100 µg |
| 24122SB | Anti-Cyclin E2 (NT) | WB, IHC | Cyclin E2 level is elevated in cells expressing papilloma viral oncogene | 100 µg |
| 24227SB | Anti-elF5A2 | WB, IHC | Eukaryotic initiation factor 5A2 is implicated in ovarian cancer development | 100 µg |
| 24253SB | Anti-F-box hCdc4 | WB, IHC | hCDc4 found to be mutated in a cell line derived from breast cancer | 100 µg |
| 24223SB | Anti-hADNP | WB, IHC | Human activity-dependent neuroprotective protein | 100 µg |
| 24166SB | Anti-HLM | WB, IHC | Indicator for detection in peripheral blood of metastatic tumor cells | 100 µg |
| 24132SB | Anti-human RAD17 (NT) | WB, IHC | RAD 17 has a key role in cell cycle checkpoint control | 100 µg |
| 24138SB | Anti-human SFRP5 (NT) | WB, IHC | Human secreted frizzled-related protein 5, modulator in Wnt signal transduction | 100 µg |
| 24312SB | Anti-KLK11 (Anti-Hippostatin) | WB, IHC | Serum marker for ovarian and prostatic carcinoma | 100 µg |
| 24237SB | Anti-KLK12 | WB, IHC | Kallikreins are a subgroup of serine proteases implicated in carcinogenesis | 100 µg |
| 24240SB | Anti-KLK14 | WB, IHC | Kallikreins are serine proteases which are down-regulated in certain cancers | 100 µg |
| 24211SB | Anti-KLK15** | WB, IHC | Kallikrein 15 is up-regulated in more aggressive forms of prostate cancer | 100 µg |
| 24212SB | Anti-KLK15** | WB, IHC | Kallikrein 15 is up-regulated in more aggressive forms of prostate cancer | 100 µg |
| 24235SB | Anti-KLK3 (PSA) | WB, IHC | Kallikreins are a subgroup of serine proteases implicated in carcinogenesis | 100 µg |
| 24236SB | Anti-KLK3-L3 (KLK9) | WB, IHC | Kallikreins are a subgroup of serine proteases implicated in carcinogenesis | 100 µg |
| 24234SB | Anti-KLK-L1 | WB, IHC | Kallikreins are a subgroup of serine proteases implicated in carcinogenesis | 100 µg |
| 24238SB | Anti-KLK-L2 | WB, IHC | Kallikreins are a subgroup of serine proteases implicated in carcinogenesis | 100 µg |
| 24239SB | Anti-KLK-L4 | WB, IHC | Kallikreins are a subgroup of serine proteases implicated in carcinogenesis | 100 µg |
| 24269SB | Anti-MAP126 | WB, IHC | Involved in functional and dynamic regulation of mitotic spindles | 100 µg |
| 24124SB | Anti-MCT-1 (NT) | WB, IHC | MCT-1 is involved in cell cycle progression and malignant transformation | 100 µg |
| 24194SB | Anti-MMP-9 (CT) | WB, IHC | MMP-9 contributes to skin carcinogenesis | 100 µg |
| 24193SB | Anti-MMP-9 (NT) | WB, IHC | MMP-9 contributes to skin carcinogenesis | 100 µg |
| 24219SB | Anti-Monopolin (Mam1) | WB, IHC | Kinetochore protein required for segregation of homologs during meiosis I | 100 µg |
| 24176SB | Anti-MUC12 (CT) | WB, IHC | MUC12 may be involved in epithelial cell growth regulation | 100 µg |
| 24175SB | Anti-MUC12 (NT) | WB, IHC | MUC12 may be involved in epithelial cell growth regulation | 100 µg |
| 24174SB | Anti-NKIAMRE (CT) | WB, IHC | Novel cyclin-dependent, kinase-related protein | 100 µg |
| 24173SB | Anti-NKIAMRE (NT) | WB, IHC | Novel cyclin-dependent, kinase-related protein | 100 µg |
| 24185SB | Anti-p21 | WB, IHC | p21 Cdk-interacting protein Cip 1 is a potent inhibitor of G1 Cdks | 100 µg |
| 24260SB | Anti-PRAC | WB, IHC | Expressed in human prostate, prostate cancer, rectum and distal colon | 100 µg |
| 24230SB | Anti-Prostein (NT) | WB, IHC | Novel protein expressed in normal and malignant prostate tissue | 100 µg |
| 24231SB | Anti-PSDR1 | WB, IHC | Prostate short-chain dehydrogenase /reductase 1 | 100 µg |
| 24134SB | Anti-PTCH1 | WB, IHC | Human patched gene mutations may be associated with certain carcinomas | 100 µg |
| 24135SB | Anti-PTCH2 | WB, IHC | Human patched gene mutations may be associated with certain carcinomas | 100 µg |
| 24117SB | Anti-RFLAT-1 Protein (NT) | WB, IHC | RANTES factor of late T-lymphocytes-1 | 100 µg |
| 24262SB | Anti-RGS8 | WB, IHC | RGS8 is involved in hereditary prostate cancer | 100 µg |
| 24282SB | Anti-Trp-p8 | WB, IHC | trp-p8 appears to be elevated in prostate cancer | 100 µg |
| 24265SB | Anti-TSKS | WB, IHC | Testis-specific kinase substrate is down-regulated in cancerous testicular tissue | 100 µg |
| 24131SB | Anti-yeast RAD17 (NT) | WB, IHC | RAD 17 has a key role in cell cycle checkpoint control | 100 µg |
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shipped on blue ice; store at -20°C (once thawed, store at 4°C to avoid multiple freezing and thawing); antibody source rabbit Abbreviations: * h.: human, m.: mouse, r. : rat, tested in: WB: Western blot, IP: immunoprecipitation, IHC: immunohistochemistry, AI: apoptose induction, I: inhibition, CT: C-terminus, NT: N-terminus, IN: intermediate domain, ED: extracellular domain, ID: intracellular domain. Control lysates of cell lines and tissues and blocking peptides are available for testing upon request. |
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Antibodies and Antigens for Oncology
For a detailed data sheet as a pdf-file, please click on the product No.| LIST OF ANTIBODIES: ORDER INFORMATION, SHIPPING AND STORAGE | |||||
| order # | product | host | form | applic* | quantity |
| Calcitonin | |||||
| A4111.1ID | anti-human Calcitonin | sheep | serum | r | 20 µl |
| A4111.2ID | anti-human Calcitonin | sheep | serum | r | 100 µl |
| A4112.1ID | anti-human Calcitonin | rabbit | serum | r | 20 µl |
| A4112.2ID | anti-human Calcitonin | rabbit | serum | r | 100 µl |
| Carcinoembryonic Antigen (CEA) | |||||
| A7221.1ID A7221.2ID |
anti-human Carcinoembryonic Antigen | goat | serum | r | 20 µl 100 µl |
| A7222.1ID A7222.2ID |
anti-human Carcinoembryonic Antigen | rabbit | serum | r | 20 µl 100 µl |
| A7222AG1ID A7222AG2ID |
human Carcinoembryonic Antigen | - | native protein | - | 10 µg 100 µg |
| Epidermal Growth Factor-Receptor (EGF-R) | |||||
| A3006.1ID A3006.2ID |
anti-human Epidermal Growth Factor-Receptor (EGF-R) | rabbit | serum | e, w | 20 µl 100 µl |
| AK3007.1ID AK3007.2ID |
anti-human Epidermal Growth Factor-Receptor (extracellular ligand binding site); clone isotype EGF-R1 IgG1 | mouse | mAb | e, im, p, f | 10 µg 100 µg |
| AK3008.1ID AK3008.2ID |
anti-human Epidermal Growth Factor-Receptor (extracellular non ligand binding site); clone isotype EGF-R2 IgG1 | mouse | mAb | e, im, p, c, f | 10 µg 100 µg |
| A1016AG.1ID | human Epidermal Growth Factor-Receptor (native) | - | antigen | - | 10 µg 100 µg |
| Gastrin | |||||
| A5511.1ID A5511.2ID |
anti-human Gastrin | rabbit | serum | r | 20 µl 100 µl |
| A5511AG.1ID A5511AG.2ID |
anti-human Gastrin | - | synthetic peptide | - | 100 µg 1 mg |
| Glutathion S-Transferase π (GST π) | |||||
| AK3102.1ID AK3102.2ID |
anti human Glutathion S-Transferaseπ; clone D2-62 IgG2a | mouse | mAb | e, r, w | 10 µg 100 µg |
| AK3105.1ID AK3105.2ID |
anti-human Glutathion S-Transferaseπ | rabbit | serum | e, r, w, im, c, p | 20 µl 100 µl |
| Parathyroid Hormone related Peptide (PTHrP) | |||||
| A7881.1ID A7881.2ID |
anti-human Parathyroid Hormone related Peptide (aa 1-30) | rabbit | serum | r | 20 µl 100 µl |
| A1118.1ID A1118.2ID |
anti-human Parathyroid Hormone related Peptide (aa 53-86) | goat | serum | r | 20 µl 100 µl |
| A4241.1ID A4241.2ID |
anti-human Parathyroid Hormone related Peptide (aa 107-111) (Osteostatin) | rabbit | serum | e | 20 µl 100 µl |
| A4242.1ID A4242.2ID |
anti-human Parathyroid Hormone related Peptide (aa 107-111) (Osteostatin) | sheep | serum | e | 20 µl 100 µl |
| A7881AG.1ID A7881AG.2ID |
human Parathyroid Hormone related Peptide (aa 1-30) | - | synthetic peptide | - | 100 µg 1 mg |
| A1118AG.1ID A1118AG.2ID |
human Parathyroid Hormone related Peptide (aa 53-86) | - | synthetic peptide | - | 100 µg 1 mg |
| A4241.AG1ID A4241.AG2ID |
human Parathyroid Hormone related Peptide (aa 107-111) (Osteostatin) | - | synthetic peptide | - | 100 µg 1 mg |
| Plasminogen Activator Inhibitor (PAI) | |||||
| A7621.1ID A7621.2ID |
anti-human Plasminogen Activator Inhibitor 1 | goat | serum | e, r, im, c, p | 10 µl 100 µl |
| A7621.3ID A7621.4ID |
anti-human Plasminogen Activator Inhibitor 1 | goat | IgG | e, r, im, c, p | 10 µg 100 µg |
| A7631.1ID A7631.2ID |
anti-human Plasminogen Activator Inhibitor 2 | goat | serum | w, e, im, p, c | 20 µl 100 µl |
| A7621AG.1ID A7621AG.2ID |
human Plasminogen Activator Inhibitor 1 | - | antigen | - | 10 µg 50 µg |
| A7631AG.1ID A7631AG.2ID |
human Plasminogen Activator Inhibitor 2 | - | antigen | - | 10 µg 100 µg |
| Tissue Plasminogen Activator Inhibitor (tPA) | |||||
| A7641.1ID A7641.2ID |
anti-human Tissue Plasminogen Activator | goat | serum | im, c, p | 20 µl 100 µl |
| Urokinase Plasminogen Activator (uPA) | |||||
| A7611.1ID A7611.2ID |
anti-human Urokinase Plasminogen Activator | goat | serum | e, im, c, p | 20 µl 100 µl |
| Urokinase Plasminogen Activator-Receptor (uPA-R) | |||||
| A7612.1ID A7612.2ID |
anti-human Urokinase Plasminogen Activator-Receptor | goat | serum | e, im, c, p | 20 µl 100 µl |
| Prostatic Acid Phosphatase (PAP) | |||||
| A7411.1ID A7411.2ID |
anti-human Prostatic Acid Phosphatase | goat | serum | - | 20 µl 100 µl |
| Thymosin β10 | |||||
| A9562.1ID A9562.2ID |
anti-human Thymosin β10 (aa 1-12) | rabbit | serum | e | 20 µl 100 µl |
| A9561.1ID A9561.2ID |
anti-human Thymosin β10 (aa 1-14) | rabbit | serum | e | 20 µl 100 µl |
| A9560.1ID A9560.2ID |
anti-human Thymosin β10 (aa 38-43) | rabbit | serum | e | 20 µl 100 µl |
| A9563AG.1ID A9563.AG.1ID |
human Thymosin β10 | - | synthetic peptide | - | 100 µg 1 mg |
| A9562AG.1ID A9562AG.2ID |
human Thymosin β10 (aa 1-12) | - | synthetic peptide | - | 100 µg 1 mg |
| A9561AG.1ID A9561AG.2ID |
human Thymosin β10 (aa 1-14) | - | synthetic peptide | - | 100 µg 1 mg |
| A9567AG.1ID A9567AG.2ID |
human Thymosin β10 (aa 7-30) | - | synthetic peptide | - | 100 µg 1 mg |
| A9568AG.1ID A9568AG.2ID |
human Thymosin β10 (aa 13-42) | - | synthetic peptide | - | 100 µg 1 mg |
| A9565AG.1ID A9565AG.2ID |
human Thymosin β10 (aa 13-43) | - | synthetic peptide | - | 100 µg 1 mg |
| A9564AG.1ID A9564AG.2ID |
human Thymosin β10 (aa 25-42) | - | synthetic peptide | - | 100 µg 1 mg |
| A9566AG.1ID A9566AG.2ID |
human Thymosin β10 (aa 25-43) | - | synthetic peptide | - | 100 µg 1 mg |
| A9560AG.1ID A9560AG.2ID |
human Thymosin β10 (aa 38-43) | - | synthetic peptide | - | 100 µg 1 mg |
| Thyroglobulin | |||||
| AK3120.1ID AK3120.2ID |
anti-human Thyroglobulin; clone PB2 IgG2 | mouse | mAb | e, i | 10 µg 100 µg |
| A3122.1ID A3122.2ID |
anti-human Thyroglobulin; clone ÜS3 IgG2 | mouse | mAb | e, i | 10 µg 100 µg |
| AK3123.1ID AK3123.2ID |
anti-human Thyroglobulin; clone PB3 IgG2 | mouse | mAb | e, i | 10 µg 100 µg |
| AK3121.1ID AK3121.2ID |
anti-human Thyroglobulin | rabbit | serum | e, i | 20 µl 100 µl |
| AK3122AG.1ID AK3122AG.2ID |
human Thyroglobulin | - | native protein | - | 10 µg 100 µg |
| Transforming Growth Factor β1 (TGF-β 1) | |||||
| RP1000ID | human Transforming Growth Factor β1 | - | native protein | - | 1 µg |
| Tumor Necrosis Factor α (TNFα) | |||||
| AK3110.1ID AK3110.2ID |
anti-human Tumor Necrosis Factor-α, clone tnfa9.9 IgG1 | mouse | mAb | e, r, w | 10 µg 100 µg |
| shipped at RT or on blue ice; store lyophilized product at 2-8°C, the dissolved product at -20°C. Abbreviavions: aa: amino acid; c: cryo-section; e: ELISA; f: flow cytometry; h: human; i: IRMA; r: RIA; r:rat; w: Western Blot; P: Paraffin-Section; im: Immunohistochemistry |
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Control Antibodies
All control immunoglobulins are obtained from serum of animals that have not been immunized. The antibodies were purified by DEAE-column chromatography.
For a detailed data sheet as a pdf-file, please click on the product.
| LIST OF ANTIBODIES: ORDER INFORMATION, SHIPPING AND STORAGE | ||
| 3703PR | Normal Rabbit IgG Antibody | 100 µg |
| 3705PR | Normal Goat IgG Antibody | 100 µg |
| 3707PR | Normal Chicken IgY Antibody | 100 µg |
| 100 µg is supplied in 100 µl of PBS containing 0.02% sodium azide. Store at 4°C, stable for one year. | ||
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