products | Cell Biology and Antibodies | Antibodies for Immune System & Cytokine Signaling

Cell Biology and Antibodies

	Antibodies for Apoptosis
	Antibodies for Immune System & Cytokine Signaling
	Antibodies for Signal Transduction, Chemokine & Hormone Receptors, Nuclear Proteins & Kinases
	Antibodies for Neurobiology
	Antibodies for Cancer Research
	Antibodies & Antigens for Infectious Diseases
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	Antibodies for Cytokines & Chemokines
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Antibodies for Immune System & Cytokine Signaling

Cytokines play an important role in the regulation of immune functions (i.e. immune responses) mediating the communication between various hematopoietic cells and influencing lymphocyte development.
Recently, new cytokines have been discovered designated IL-21 and IL-22. The latter is an IL-10 homologue which is produced by activated T-cells. It may be involved in inflammation because it induces the production of acute-phase reactants in vitro and in vivo.
IL-22 binds to and signals through CRF2-4, a member of the class II cytokine receptor family which also includes IL-10R. IL-22R, a new member of the interferon receptor family, functions as a second component together with CRF2-4 to enable IL-22 signaling.
IL-21 is an exciting new member of the cytokine family which influences lymphoid differentiation and is probably used by T-cells to stimulate effector functions in an autocrine and paracrine fashion. It has structural homologies with IL-15, IL-4 as well as IL-2 and has been found to have potent effects on all classes of lymphocytes (B, T and natural killer cells). IL-21 may substantially increase the cytotoxic activity of mature natural killer cells.

The IL-21 receptor shows significant homologies to the IL-2, IL-4 and IL-9 type I receptors. It is expressed by activated T-cells. A further new member of the type I cytokine receptor family that plays a part in the T-cell differentiation is designated TCCR (T-cell cytokine receptor).

Western blot analysis of IL-21 expression in HL-60 cell lysate in the absence (lane A) and pres-ence (lane B) of blocking peptide with anti-IL-21 (IN) at 1 µg/ml.

* h.: human, m.: mouse, r. : rat, tested in: WB: Western blot,
CT: C-terminus,
NT: N-terminus,
IN: internal,
ED: extracellular domain,
ID: intracellular domain.
Control lysates of cell lines and tissues and blocking peptides are available for testing upon request.

For a detailed data sheet as a pdf-file, please click on the product No.

LIST OF ANTIBODIES: ORDER INFORMATION, SHIPPING AND STORAGE
order #	product	reactive*	applic.*	description	amount
24201SB	Anti-CD100**	h.	WB,IHC	Interacts with CD72	100 µg
24202SB	Anti-CD100**	h.	WB,IHC	Interacts with CD72	100 µg
24144SB	Anti-CD28	h.	WB,IHC	T-cell specific cell-surface receptor	100 µg
24200SB	Anti-CD72	h.	WB,IHC	Lymphocyte receptor, B cell signaling	100 µg
24199SB	Anti-CD72 (NT)	h.	WB,IHC	Lymphocyte receptor, B cell signaling	100 µg
24118SB	Anti-IL18BP (NT)	h.	WB,IHC	Interleukin-18 binding protein	100 µg
2465PR	Anti-IL21 (CT)	h.	WB	Newly identified cytokine	100 µg
2469PR	Anti-IL21R (ED)	h.	WB	New class I cytokine receptor	100 µg
2471PR	Anti-IL21R (NT)	h.	WB	New class I cytokine receptor	100 µg
2489PR	Anti-IL22R (CT)	h.	WB	New class II cytokine receptor	100 µg
2497PR	Anti-IL22R (NT)	h.	WB	New class II cytokine receptor	100 µg
24233SB	Anti-IRTA1	h.	WB,IHC	Immunglobulin receptor	100 µg
24248SB	Anti-IRTA2	h.	WB,IHC	Immunglobulin receptor	100 µg
24195SB	Anti-NFATc1**	h.	WB,IHC	T and B cell activation and differentiation	100 µg
24196SB	Anti-NFATc1**	h.	WB,IHC	T and B cell activation and differentiation	100 µg
24198SB	Anti-NFATc2**	h.	WB,IHC	T and B cell activation and differentiation	100 µg
2483PR	Anti-TCCR (CT)	h.	WB	New T-cell cytokine receptor	100 µg
2481PR	Anti-TCCR (NT)	h.	WB	New T-cell cytokine receptor	100 µg
shipped on blue ice; stored at -20°C (once thawed, stored at 4°C to avoid multiple freezing and thawing)

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See also chapter 5 of our online catalog.