Potentially more applications possible than tested so far.

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Antibodies for Signal Transduction, Chemokine & Hormone Receptors, Nuclear Proteins & Kinases

Polyclonal antibodies against
  • IL-1R associated kinase and accessory protein
  • JAK activated transcription factor
  • adapters in IL-1 and LPS signaling
     

Signal transduction provides a means for communication at the cellular level. The movement of signals from outside the cell to the inside can be simple, like that associated with receptors constituting channels which, upon ligand interaction, allow passage of small ions. These ion movements result in changes in the electrical potential of the cells that, in turn, propagates the signal along the cell.
More complex signal transduction involves the coupling of ligand-receptor interactions to many intracellular events which often constitute cascade-like pathways. These events include phosphorylations of distinct amino acids by specific kinases which change enzyme activities and protein conformations. This eventually results in an alteration of cellular activity and changes in the program of genes expressed within the responding cells.
Western blot analysis of 50 µg of whole cell lysate from HeLa (H), Jurkat (J), A431 (A), K562 (K), and NIH3T3 (N) cells, respectively, with anti-STAT1a at 1:1000 dilution. 
 Western blot analysis of 50 µg of whole cell lysate from HeLa (H), Jurkat (J), A431 (A), K562 (K), and NIH3T3 (N) cells, respectively, with anti-STAT1a at 1:1000 dilution.


For a detailed data sheet as a pdf-file, please click on the product No.
LIST OF ANTIBODIES: ORDER INFORMATION, SHIPPING AND STORAGE
order # product reactive* applic.* description amount
Signal transduction
2499PR Anti-CIKS (CT) h. WB Activator of IKK, ATF and AP-1 100 µg
2501PR Anti-CIKS (NT) h. WB Activator of IKK, ATF and AP-1 100 µg
24259SB Anti-hPIP1 h. WB,IHC Human PAK-interacting protein 100 µg
24164SB Anti-IKAP (CT) h. WB,IHC Inflammatory cytokine signaling 100 µg
24163SB Anti-IKAP (NT) h. WB,IHC Inflammatory cytokine signaling 100 µg
2025PR Anti-IKKa (C1) h. WB, IHC IkB serine protein kinase alpha 100 µg
2115PR Anti-IKKa (C2) h. WB IkB serine protein kinase alpha 100 µg
2117PR Anti-IKKa (C3) h. WB IkB serine protein kinase alpha 100 µg
2121PR Anti-IKKb (C3) h. WB IkB serine protein kinase beta 100 µg
2329PR Anti-IKKe/IKK-I (CT) h. WB IkB kinase epsilon 100 µg
24162SB Anti-IKKg (CT) h. WB,IHC IkB kinase gamma 100 µg
24161SB Anti-IKKg (NT)** h. WB,IHC IkB kinase gamma 100 µg
2335PR Anti-IKKg/NEMO (NT)** h. m. r. WB IkB kinase gamma 100 µg
2131PR Anti-IL-1RAcP (C1) h. WB IL-1 receptor accessory protein 100 µg
2129PR Anti-IL-1RAcP (C2) h. WB IL-1 receptor accessory protein 100 µg
1007PR Anti-IRAK (CT) h. WB, IP IL-1 receptor associated kinase 100 µg
2123PR Anti-IRAK2 (C2) h. WB IL-1R receptor associated kinase 100 µg
2213PR Anti-IRAK-2 (CT) h. WB IL-1R receptor associated kinase 100 µg
3125PR Anti-IRAK-4 h. WB A member in IRAK/Pelle family 100 µg
2355PR Anti-IRAK-M h. m. r. WB Novel IL-1R associated kinase 100 µg
24229SB Anti-Kidins220** h. WB,IHC Kinase D-interacting substrate 100 µg
24251SB Anti-Kidins220** h. WB,IHC Kinase D-interacting substrate 100 µg
24332SB Anti-Kos1 m. WB, IHC Nonreceptor protein tyrosine kinase 100 µg
1150PR Anti-MADD (CT) h. WB MAPK pathway activator 100 µg
2127PR Anti-MyD88 (CT) h. WB Adapter in IL-1 and LPS signaling 100 µg
2125PR Anti-MyD88 (IN) h. m. WB Adapter in IL-1 and LPS signaling 100 µg
2351PR Anti-NAK/TBK1 (CT) h. m. WB NF-kappaB activating kinase 100 µg
1129PR Anti-NIK (CT) h. WB NFkB inducing kinase 100 µg
1107PR Anti-p62DOK (CT) h. WB Tyrosine kinase substrate 100 µg
24314SB Anti-PAPK m. WB, IHC Novel polyploidy-associated protein kinase 100 µg
24222SB Anti-PKD2 h. WB,IHC Protein kinase D2, ser/thr kinase 100 µg
24287SB Anti-SERPINB10 h. WB,IHC Inh. of trypsin-like ser-proteases 100 µg
24285SB Anti-SERPINB12 h. WB,IHC Inh. of trypsin-like ser-proteases 100 µl
24286SB Anti-SERPINB13 h. WB,IHC Inh. of trypsin-like ser-proteases 100 µg
1125PR Anti-SIRPa (CT) h. WB Tyrosine kinase substrate 100 µg
1021PR Anti-STAT1a (CT) h. WB, IP JAK activated transcription factor 100 µg
3385PR Anti-TAK1 (NT) (MAP3K7) h. m. r. WB, IP TGF-beta activated protein kinase 100 µg
3129PR Anti-TRAF6(CT) h. m. r. WB TNF receptor associated factor 100 µg
order # product reactive* applic.* description amount
Nuclear proteins and hormone receptors
24139SB Anti-Alien h. WB, IHC Interacting with thyroid hormone receptor 100 µg
24178SB Anti-hp8/com1 (CT) h. WB, IHC Nuclear protein with strong mitogenic activity 100 µg
24177SB Anti-hp8/com1 (NT) h. WB, IHC Nuclear protein with strong mitogenic activity 100 µg
24228SB Anti-RanBP17 h. WB, IHC RanGTP-binding protein, nuclear receptor 100 µg
HIV coreceptors and chemokine receptors
1170PR Anti-Bonzo (CT) h. WB HIV coreceptor 100 µg
2209PR Anti-Bonzo (NT2) h. WB HIV coreceptor 100 µg
1112PR Anti-CCR5 (NT) h. WB HIV and chemokine receptor 100 µg
2097PR Anti-CCR8 (EL) h. WB HIV and chemokine receptor 100 µg
2201PR Anti-CX3CR1 (EL) h. WB HIV and chemokine receptor 100 µg
2093PR Anti-CX3CR1 (NT) h. WB HIV and chemokine receptor 100 µg
1012PR Anti-CXCR4 (EL) h. WB HIV and chemokine receptor 100 µg
1009PR Anti-CXCR4 (NT) h. WB, IP, IHC HIV and chemokine receptor 100 µg
2347PR Anti-DC-SIGN (CT) h. WB dendritic HIV-binding protein 100 µg
2349PR Anti-DC-SIGN (ED) h. WB dendritic HIV-binding protein 100 µg
1123PR Anti-Eotaxin (CT) h. WB CCR3 ligand 100 µg
2101PR Anti-GPR15/BOB (NT) h. WB HIV coreceptor 100 µg
shipped on blue ice; storage: see respective data sheet
antibody source: rabbit
Abbreviations:
* h.: human, m.: mouse, r. : rat, tested in: WB: Western blot, IP: immunoprecipitation,
IHC: immunohistochemistry, AI: apoptose induction, I: inhibition, Inh.: Inhibitor
CT: C-terminus; C1, C2, C3: C-termini 1, 2 and 3, NT: N-terminus, IN: intermediate domain,
ED: extracellular domain, ID: intracellular domain.
Control lysates of cell lines and tissues and blocking peptides are available for testing upon request.
**: different antigen-targets

 

Control Antibodies

All control immunoglobulins are obtained from serum of animals that have not been immunized. The antibodies were purified by DEAE-column chromatography.


For a detailed data sheet as a pdf-file, please click on the product No.
LIST OF ANTIBODIES: ORDER INFORMATION, SHIPPING AND STORAGE
order# product amount
3703PR Normal Rabbit IgG Antibody 100 µg
3705PR Normal Goat IgG Antibody 100 µg
3707PR Normal Chicken IgY Antibody 100 µg
100 µg is supplied in 100 µl of PBS containing 0.02% sodium azide. Store at 4°C, stable for one year.


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