US Patents

This list of Molecular Probes' patents and published patent applications is complete as of June 7, 2002. Patents issued subsequent to that date are listed at our Web site (http://www.probes.com). We welcome inquiries about Licensing these patents.

Patent Number	Name of Patent	Inventors
US 4,774,339	Chemically Reactive Dipyrrometheneboron Difluoride Dyes	Richard P. Haugland Hee Chol Kang
US 4,945,171	Xanthene Dyes Having a Fused [C] Benzo Ring	Richard P. Haugland James E. Whitaker
US 5,132,432	Chemically Reactive Pyrenyloxy Sulfonic Acid Dyes	Richard P. Haugland James E. Whitaker
US 5,187,288	Ethenyl-Substituted Dipyrrometheneboron Difluoride Dyes and Their Synthesis	Hee Chol Kang Richard P. Haugland
US 5,208,148	Lipophilic Fluorescent Glycosidase Substrates	Richard P. Haugland John J. Naleway Yu-zhong Zhang
US 5,227,487	Certain Tricyclic and Pentacyclic-Hetero Nitrogen Rhodol Dyes	Richard P. Haugland James E. Whitaker
US 5,242,805	Long Wavelength Lipophilic Fluorogenic Glycosidase Substrates	John J. Naleway Yu-zhong Zhang Richard P. Haugland
US 5,248,782	Long Wavelength Heteroaryl-Substituted Dipyrrometheneboron Difluoride Dyes	Richard P. Haugland Hee Chol Kang
US 5,262,545	Fluorescent Chloramphenicol Derivatives for Determination of Chloramphenicol Acetyltransferase Activity	Richard P. Haugland Hee Chol Kang Steven L. Young Michael H. Melner
US 5,274,113	Long Wavelength Chemically Reactive Dipyrrometheneboron Difluoride Dyes and Conjugates	Hee Chol Kang Richard P. Haugland
US 5,314,805	Dual-Fluorescence Cell Viability Assay Using Ethidium Homodimer and Calcein AM	Richard P. Haugland Ian C. MacCoubrey Patrick L. Moore
US 5,316,906	Enzymatic Analysis Using Substrates That Yield Fluorescent Precipitates	Richard P. Haugland Yu-zhong Zhang Stephen T. Yue Ewald Terpetschnig Nels A. Olson John J. Naleway
US 5,321,130	Unsymmetrical Cyanine Dyes With Cationic Side Chains	Stephen T. Yue Iain D. Johnson Zhijian Huang Richard P Haugland
US 5,326,692	Fluorescent Microparticles With Controllable Enhanced Stokes Shift	John M. Brinkley Richard P. Haugland Victoria Singer
US 5,338,854	Fluorescent Fatty Acids Derived from Dipyrrometheneboron Difluoride Dyes	Hee Chol Kang Richard P. Haugland
US 5,362,628	Fluorescent Haloalkyl Derivatives of Reporter Molecules Well Retained in Cells	Richard P. Haugland Yu-zhong Zhang John J. Naleway Rosaria P. Haugland
US 5,364,764	Fluorescent Chloramphenicol Derivatives for Determination of Chloramphenicol Acetyltransferase Activity	Richard P. Haugland Hee Chol Kang Steven L. Young Michael H. Melner
US 5,405,975	Fluorescent Ion-Selective Diaryldiaza Crown Ether Conjugates	Michael A. Kuhn Richard P. Haugland
US 5,410,030	Dimers of Unsymmetrical Cyanine Dyes Containing Pyridinium Moieties	Stephen T. Yue Richard P. Haugland
US 5,433,896	Dibenzopyrrometheneboron Difluoride Dyes	Hee Chol Kang Richard P. Haugland
US 5,436,134	Cyclic-Substituted Unsymmetrical Cyanine Dyes	Richard P. Haugland Stephen T. Yue Paul J. Millard Bruce L. Roth
US 5,437,980	Phenanthridium Dye Staining of Nucleic Acids in Living Cells	Richard P. Haugland
US 5,442,045	Biological Conjugates of Fluorescent Rhodol Dyes	Richard P. Haugland James E. Whitaker
US 5,443,986	Enzymatic Analysis Using Substrates That Yield Fluorescent Precipitates	Richard P. Haugland Zhijian Huang Karen D. Larison Yu-zhong Zhang
US 5,445,946	Viability Stains for Yeast and Other Fungi	Bruce L. Roth Paul J. Millard Stephen T. Yue Richard P. Haugland
US 5,451,663	Long Wavelength Chemically Reactive Dipyrrometheneboron Difluoride Dyes and Conjugates	Richard P. Haugland Hee Chol Kang
US 5,453,517	Reactive Derivatives of BAPTA Used to Make Ion-Selective Chelators	Michael A. Kuhn Richard P. Haugland
US 5,459,268	Xanthylium Dyes That Are Well Retained In Mitochondria	Richard P. Haugland Nabi Malekzadeh Yu-zhong Zhang
US 5,459,276	Benzazolylcoumarin-based Ion Indicators For Heavy Metals	Michael A. Kuhn Richard P. Haugland Brian Matthew Hoyland
US 5,501,980	Benzazolylcoumarin-based Ion Indicators	Haralambos E. Katerinopoulos Eleni Iatridou Evangelia Foukaraki Mohammad N. Malekzadeh Michael A. Kuhn Richard P. Haugland
US 5,514,710	Photocleavable Derivatives of Hydroxypyrenesulfonic Acids	Richard P. Haugland Kyle Richard Gee
US 5,516,864	Fluorescent Ion-Selective Diaryldiaza Crown Ether Conjugates	Michael A. Kuhn Richard P. Haugland
US 5,534,416	Fluorescent Viability Assay Using Cyclic-Substituted Unsymmetrical Cyanine Dyes	Paul J. Millard Bruce L. Roth Stephen T. Yue Richard P. Haugland
US 5,545,535	Fluorescent Assay for Bacterial Gram Reaction	Bruce L.Roth Paul J. Millard Stephen T. Yue K. Sam Wells Richard P. Haugland
US 5,573,909	Fluorescent Labeling Using Microparticles With Controllable Stokes Shift	Victoria L. Singer Richard P. Haugland
US 5,576,424	Haloalkyl Derivatives of Reporter Molecules Used to Analyze Metabolic Activity in Cells	Fei Mao Ram Sabnis John Naleway Nels Olson Richard P. Haugland
US 5,582,977	Dimers of Unsymmetrical Cyanine Dyes	Stephen T. Yue Iain D. Johnson Richard P. Haugland
US 5,616,502	Non-specific Protein Staining Using Merocyanine Dyes	Richard P. Haugland Victoria L. Singer Laurie J. Jones Thomas H. Steinberg
US 5,635,608	Alpha-Carboxy Caged Compounds	Richard P. Haugland Kyle R. Gee
US 5,648,270	Methods of Sensing with Fluorescent Conjugates of Metal-Chelating Nitrogen Heterocycles	Michael A. Kuhn Brian Matthew Hoyland Richard P. Haugland
US 5,656,449	Neutral Unsymmetrical Cyanine Dyes	Stephen T. Yue
US 5,658,751	Substituted Unsymmetrical Cyanine Dyes with Selected Permeability	Stephen T. Yue Victoria L. Singer Bruce L. Roth Thomas J. Mozer Paul J. Millard Laurie J. Jones Xiaokui Jin Richard P. Haugland
US 5,686,261	Xanthylium Dyes that are Well Retained in Mitochondria	Yu-zhong Zhang Richard P. Haugland
US 5,696,157	Sulfonated Derivatives of 7-Aminocoumarins	Hui Ying Wang Wai-Yee Leung Fei Mao
US 5,719,031	Dye Labeled Polymers as Reagents for Measuring Polymer Degradation	Richard P. Haugland Mingjie Zhou
US 5,723,218	Dipyrrometheneboron Difluoride Labeled Fluorescent Microparticles	Richard P. Haugland Rosaria P. Haugland John Michael Brinkley Hee Chol Kang Michael Kuhn K. Sam Wells Yu-zhong Zhang
US 5,773,227	Bifunctional Chelating Polysaccharides	Michael A. Kuhn Tobias Meyer Nancy L. Allbritton
US 5,773,236	Polyhaloaryl-Substituted Reporter Molecules	Zhenjun Diwu Richard P. Haugland
US 5,786,219	Microspheres with Fluorescent Spherical Zones	Yu-zhong Zhang Courtenay R. Kemper Richard P. Haugland
US 5,798,276	Reactive Derivatives of Sulforhodamine 101 with Enhanced Hydrolytic Stability	Richard P. Haugland Wojciech Szalecki
US 5,830,912	Derivatives of 6,8-Difluoro-7-hydroxycoumarin	Kyle R. Gee Richard P. Haugland Wei-Chuan Sun
US 5,846,737	Conjugates of Sulforhodamine Fluorophores with Enhanced Fluorescence	Hee Chol Kang
US 5,863,753	Chemically Reactive Unsymmetrical Cyanine Dyes and their Conjugates	Richard P. Haugland Victoria L. Singer Stephen T. Yue Paul J. Millard
US 5,869,689	Stains for Acidic Organelles	Yu-zhong Zhang Zhenjun Diwu Richard P. Haugland
US 5,872,243	Novel Caged Nucleotides	Kyle R. Gee Hon Cheung Lee Robert Aarhus Richard P. Haugland Timothy F. Walseth Richard M. Graeff
US 5,888,829	Photolabile Caged Ionophores	Kyle R. Gee Paul J. Millard
US 6,004,536	Lipophilic Cyanine Dyes with Enhanced Aqueous Solubility	Wai-Yee Leung Richard P. Haugland Fei Mao
US 6,005,113	Long Wavelength Dyes for Infrared Tracing	Yexin Wu Dieter H. Klaubert Hee Chol Kang Yu-Zhong Zhang
US 6,013,802	Fluorescent Conjugates of Metal-Chelating Nitrogen Heterocycles	Brian Matthew Hoyland Michael A. Kuhn Richard P. Haugland
US 6,130,101	Sulfonated Xanthene Derivatives	Fei Mao Wai-Yee Leung Richard P. Haugland
US 6,162,931	Fluorinated Xanthene Derivatives	Kyle R. Gee Martin Poot Dieter H. Klaubert Wei-Chuan Sun Richard P. Haugland Fei Mao
US 6,229,055	Synthesis of Fluorinated Xanthene Derivatives	Dieter H. Klaubert Kyle R. Gee
US 6,265,179	Detection of Phosphate using Coupled Enzymatic Reactions	Mingjie Zhou Richard P. Haugland
US 6,291,203	Cyanine Dyes that Stain Cells and Mitochondria	Martin Poot Fei Mao
US 6,316,267	Luminescent Protein Stains and Their Method of Use	Mahesh K. Bhalgat Zhenjun Diwu Richard P. Haugland Wayne F. Patton
US 6,323,337	Quenching Oligonucleotides	Victoria L. Singer Richard P. Haugland
US 6,323,186	Phosphate-Bound Polyazaindacene Derivatives of Nucleotides	Dieter H. Klaubert Kyle R. Gee Charles M. Brenner
US 6,329,205	Detection method using luminescent europium-based protein stains	Zhenjun Diwu Wayne F. Patton

International Patent Applications

Publication Number	Name of Application
WO 93/04077	Enzymatic Analysis Using Substrates That Yield Fluorescent Precipitates
WO 93/04192	Use of Haloalkyl Derivatives of Reporter Molecules to Analyze Metabolic Activity in Cells
WO 93/06482	Dimers of Unsymmetrical Cyanine Dyes
WO 93/09185	Long Wavelength Chemically Reactive Dipyrrometheneboron Difluoride Dyes and Conjugates
WO 93/23492	Fluorescent Microparticles with Controllable Enhanced Stokes Shift
WO 94/24213	Cyclic-Substituted Unsymmetrical Cyanine Dyes
WO 96/13552	Substituted Unsymmetrical Cyanine Dyes with Selected Permeability
WO 96/36882	Merocyanine Dye Protein Stains
WO 97/39064	Fluorinated Xanthene Derivatives
WO 99/15517	Sulfonated Xanthene Derivatives
WO 00/17650	Energy Transfer Compositions Comprising Phycobiliproteins
WO 00/25139	Luminiscent Protein Stains Containing Transition Metal Complexes
WO 00/64988	Xanthene Dyes and Their Application As Luminescence Quenching Compounds
WO 00/66664	Aza-Benzazolium Containing Cyanine Dyes

European Patents

Patent Number	Name of Patent
EP 0 641 351	Enzymatic Analysis Using Substrates That Yield Fluorescent Precipitates
EP 0 605 655	Dimers of Unsymmetrical Cyanine Dyes
EP 0 612 336	Long Wavelength Chemically Reactive Dipyrrometheneboron Difluoride Dyes and Conjugates
EP 0 596 098	Fluorescent Microparticles With Controllable Enhanced Stokes Shift
EP 0 603 266	Use of Haloalkyl Derivatives of Reporter Molecule to Analyze Metabolic Activity in Cells
EP 0 675 924	Cyclic-Substituted Unsymmetrical Cyanine Dyes

Canadian Patents

Patent Number	Name of Patent
CA 2,113,106	Fluorescent Microparticles with Controllable Enhanced Stokes Shift
CA 2,115,461	Enzymatic Analysis Using Substrates That Yield Fluorescent Precipitates
CA 2,119,126	Dimers of Unsymmetrical Cyanine Dyes
CA 2,133,765	Cyclic-Substituted Unsymmetrical Cyanine Dyes

Australian Patents

Patent Number	Name of Patent
AU 676,317	Cyclic-Substituted Unsymmetrical Cyanine Dyes
AU 699,961	Merocyanine Dye Protein Stains
AU 717,569	Fluorinated Xanthene Derivatives
AU 714,890	Substituted Unsymmentrical Cyanine Dyes with Selected Permeability

United Kingdom Patents

Patent Number	Name of Patent
GB 2 277 096	Fluorescent Ion-Selective Diaryldiaza Crown Ether Conjugates
GB 2 283 744	Xanthylium Dyes That are Well Retained in Mitochondria
GB 2 318 580	Microspheres with Fluorescent Spherical Zones
GB 2 319 250	Derivatives of 6,8-Difluoro-7-Hydroxycoumarin
GB 2 302 094	Reactive Derivatives of Sulforhodamine 101 with Enhanced Hydrolytic Stability