Chapter 18 — Probes for Signal Transduction

Table of Contents 

Section 18.1 — Introduction to Signal Transduction 

Section 18.2 — Calcium Regulation 

• Inositol Triphosphate Pathway
• D-myo-1,4,5-Inositol Triphosphate and Caged D-myo-1,4,5-Inositol Triphosphate
• Fluorescent Heparin
• Calcium-Induced Calcium Release
• Cyclic ADP Ribose and Caged Cyclic ADP Ribose
• Deaza Cyclic ADP Ribose
• Cyclic ADP Ribose Antagonist
• Ryanodine and Fluorescent Ryanodine
• Caged Ca²⁺ and Caged Ca²⁺ Chelators
• NP-EGTA: A Caged-Ca²⁺ Reagent
• DMNP-EDTA: A Caged-Ca²⁺ Reagent
• Diazo-2: A Photoactivatable Ca²⁺ Scavenger
• Other Probes for Calcium Regulation
• Thapsigargin and Fluorescent Thapsigargin
• Luminescent Calcium Analog
• Data Table
• Product List

Section 18.3 — Probes for Protein Kinases, Protein Phosphatases and Nucleotide-Binding Proteins 

• Protein Kinase C
• Protein Kinase Inhibitors and Activators
• A Fluorescent Bisindolylmaleimide: Fim-1
• Debromoaplysiatoxin
• Fluorescent Polymyxin B Analogs
• Hypericin and Hypocrellins A and B
• Antibody against a CaM Kinase II Substrate, Synapsin I
• Calmodulin and Calmodulin Conjugates
• RediPlate 96 and RediPlate 384 EnzChek Tyrosine Phosphatase Assay Kits
• Cyclic AMP Fluorosensor
• Adenylate Cyclase Probe: Fluorescent Forskolin
• Nucleotide Analogs
• BODIPY Ribonucleotide Di- and Triphosphates
• BODIPY FL AMPPNP and BODIPY FL GMPPNP
• BODIPY FL ATP--S and BODIPY FL GTP--S
• Alexa Fluor 647 ATP
• N-Methylanthraniloyl (MANT) Nucleotides
• MANT-ATP, MANT-ADP and MANT-AMPPNP
• MANT-GTP, MANT-GDP and MANT-GMPPNP
• Ethenoadenosine Nucleotides
• Trinitrophenyl (TNP) Nucleotides
• Caged Nucleotides
• Other Nucleotide Analogs
• BzBzATP and BzBzGTP
• ATP -AmNS, dATP -AmNS and UTP -AmNS
• Data Table
• Product List

Section 18.4 — Probes for Lipid Metabolism and Signaling 

• Phospholipases A₁ and A₂
• BODIPY Dye Phospholipase A Substrates
• PED6 Phospholipase A₂ Substrate
• Bis-Pyrenyl Phospholipase A Substrates
• Singly Labeled Pyrenyl and NBD Phospholipase A Substrates
• ADIFAB and DAUDA: A Different View of Phospholipase A Activity
• Phospholipases C and D
• Amplex Red Phosphatidylcholine-Specific Phospholipase C Assay Kit
• D 609: A Selective Phospholipase C Inhibitor
• Bacillus cereus PI-PLC and Anti–PI-PLC
• Phospholipase D
• Amplex Red Phospholipase D Assay Kit
• Fluorescent Substrates for Phospholipase D
• Probes for Phosphoinositide-Mediated Cellular Functions
• Fluorescent Phosphoinositides
• Shuttle PIP Carriers
• Phosphoinositide Cell-Labeling Kits
• Anti-Phosphoinositide Monoclonal Antibodies
• Arrays for Detection of Phosphoinositide–Protein Interactions
• Phosphoinositide-Coupled Agarose Beads
• Sphingolipids
• BODIPY Sphingolipids
• NBD Sphingolipids
• Arrays for Detection of Sphingolipid–Protein Interactions
• Sphingomyelinase Assay Kit
• Free Fatty Acids and Their Analogs
• ADIFAB: A Unique Free Fatty Acid Indicator
• Data Table
• Product List