Potentially more applications possible than tested so far.

products | cell biology and antibodies | Antibodies for Signal Transduction, Chemokine & Hormone Receptors, Nuclear Proteins & Kinases

Cell Biology and Antibodies

	Antibodies for Apoptosis
	Antibodies for Immune System & Cytokine Signaling
	Antibodies for Signal Transduction, Chemokine & Hormone Receptors, Nuclear Proteins & Kinases
	Antibodies for Neurobiology
	Antibodies for Cancer Research
	Antibodies & Antigens for Infectious Diseases
	Miscellaneous Antibodies
	Antibodies for Cytokines & Chemokines
	Antibacterial Antibodies

Antibodies for Signal Transduction, Chemokine & Hormone Receptors, Nuclear Proteins & Kinases

Polyclonal antibodies against

IL-1R associated kinase and accessory protein
JAK activated transcription factor
adapters in IL-1 and LPS signaling

Signal transduction provides a means for communication at the cellular level. The movement of signals from outside the cell to the inside can be simple, like that associated with receptors constituting channels which, upon ligand interaction, allow passage of small ions. These ion movements result in changes in the electrical potential of the cells that, in turn, propagates the signal along the cell.
More complex signal transduction involves the coupling of ligand-receptor interactions to many intracellular events which often constitute cascade-like pathways. These events include phosphorylations of distinct amino acids by specific kinases which change enzyme activities and protein conformations. This eventually results in an alteration of cellular activity and changes in the program of genes expressed within the responding cells.

Western blot analysis of 50 µg of whole cell lysate from HeLa (H), Jurkat (J), A431 (A), K562 (K), and NIH3T3 (N) cells, respectively, with anti-STAT1a at 1:1000 dilution.

For a detailed data sheet as a pdf-file, please click on the product No.

LIST OF ANTIBODIES: ORDER INFORMATION, SHIPPING AND STORAGE
order #	product	reactive*	applic.*	description	amount
Signal transduction
2499PR	Anti-CIKS (CT)	h.	WB	Activator of IKK, ATF and AP-1	100 µg
2501PR	Anti-CIKS (NT)	h.	WB	Activator of IKK, ATF and AP-1	100 µg
2025PR	Anti-IKKa (C1)	h.	WB, IHC	IkB serine protein kinase alpha	100 µg
2115PR	Anti-IKKa (C2)	h.	WB	IkB serine protein kinase alpha	100 µg
2117PR	Anti-IKKa (C3)	h.	WB	IkB serine protein kinase alpha	100 µg
2121PR	Anti-IKKb (C3)	h.	WB	IkB serine protein kinase beta	100 µg
2329PR	Anti-IKKe/IKK-I (CT)	h.	WB	IkB kinase epsilon	100 µg
2335PR	Anti-IKKg/NEMO (NT)**	h. m. r.	WB	IkB kinase gamma	100 µg
2131PR	Anti-IL-1RAcP (C1)	h.	WB	IL-1 receptor accessory protein	100 µg
2129PR	Anti-IL-1RAcP (C2)	h.	WB	IL-1 receptor accessory protein	100 µg
1007PR	Anti-IRAK (CT)	h.	WB, IP	IL-1 receptor associated kinase	100 µg
2123PR	Anti-IRAK2 (C2)	h.	WB	IL-1R receptor associated kinase	100 µg
2213PR	Anti-IRAK-2 (CT)	h.	WB	IL-1R receptor associated kinase	100 µg
3125PR	Anti-IRAK-4	h.	WB	A member in IRAK/Pelle family	100 µg
2355PR	Anti-IRAK-M	h. m. r.	WB	Novel IL-1R associated kinase	100 µg
1150PR	Anti-MADD (CT)	h.	WB	MAPK pathway activator	100 µg
2127PR	Anti-MyD88 (CT)	h.	WB	Adapter in IL-1 and LPS signaling	100 µg
2125PR	Anti-MyD88 (IN)	h. m.	WB	Adapter in IL-1 and LPS signaling	100 µg
2351PR	Anti-NAK/TBK1 (CT)	h. m.	WB	NF-kappaB activating kinase	100 µg
1129PR	Anti-NIK (CT)	h.	WB	NFkB inducing kinase	100 µg
1107PR	Anti-p62DOK (CT)	h.	WB	Tyrosine kinase substrate	100 µg
1125PR	Anti-SIRPa (CT)	h.	WB	Tyrosine kinase substrate	100 µg
1021PR	Anti-STAT1a (CT)	h.	WB, IP	JAK activated transcription factor	100 µg
3385PR	Anti-TAK1 (NT) (MAP3K7)	h. m. r.	WB, IP	TGF-beta activated protein kinase	100 µg
3129PR	Anti-TRAF6(CT)	h. m. r.	WB	TNF receptor associated factor	100 µg
HIV coreceptors and chemokine receptors
1170PR	Anti-Bonzo (CT)	h.	WB	HIV coreceptor	100 µg
2209PR	Anti-Bonzo (NT2)	h.	WB	HIV coreceptor	100 µg
1112PR	Anti-CCR5 (NT)	h.	WB	HIV and chemokine receptor	100 µg
2097PR	Anti-CCR8 (EL)	h.	WB	HIV and chemokine receptor	100 µg
2201PR	Anti-CX3CR1 (EL)	h.	WB	HIV and chemokine receptor	100 µg
2093PR	Anti-CX3CR1 (NT)	h.	WB	HIV and chemokine receptor	100 µg
1012PR	Anti-CXCR4 (EL)	h.	WB	HIV and chemokine receptor	100 µg
1009PR	Anti-CXCR4 (NT)	h.	WB, IP, IHC	HIV and chemokine receptor	100 µg
2347PR	Anti-DC-SIGN (CT)	h.	WB	dendritic HIV-binding protein	100 µg
2349PR	Anti-DC-SIGN (ED)	h.	WB	dendritic HIV-binding protein	100 µg
1123PR	Anti-Eotaxin (CT)	h.	WB	CCR3 ligand	100 µg
2101PR	Anti-GPR15/BOB (NT)	h.	WB	HIV coreceptor	100 µg
shipped on blue ice; storage: see respective data sheet antibody source: rabbit Abbreviations: * h.: human, m.: mouse, r. : rat, tested in: WB: Western blot, IP: immunoprecipitation, IHC: immunohistochemistry, AI: apoptose induction, I: inhibition, Inh.: Inhibitor CT: C-terminus; C1, C2, C3: C-termini 1, 2 and 3, NT: N-terminus, IN: intermediate domain, ED: extracellular domain, ID: intracellular domain. Control lysates of cell lines and tissues and blocking peptides are available for testing upon request. **: different antigen-targets

Control Antibodies

All control immunoglobulins are obtained from serum of animals that have not been immunized. The antibodies were purified by DEAE-column chromatography.

For a detailed data sheet as a pdf-file, please click on the product No.

LIST OF ANTIBODIES: ORDER INFORMATION, SHIPPING AND STORAGE
order#	product	amount
3703PR	Normal Rabbit IgG Antibody	100 µg
3705PR	Normal Goat IgG Antibody	100 µg
3707PR	Normal Chicken IgY Antibody	100 µg
100 µg is supplied in 100 µl of PBS containing 0.02% sodium azide. Store at 4°C, stable for one year.

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