Amino Acid-Preloaded Hydrazide Resins for Generation of Peptide Thioester
Generation of Peptide Thioester on AA Hydrazide Resins
A peptide hydrazide is generated after SPPS and cleavage and converted into a peptide thioester.
Bioconjugation via NCL
Generated peptide thioester can be conjugated by NCL between an unprotected C-terminal thioester peptide and a Cys/Ala-containing peptide/protein. Peptide thioesters are commonly used for bioconjugation to proteins, dyes, drugs like DOTA, or printing to glass surfaces.
- Preloaded with 19 L- & 19 D-isomer amino acids
- For synthesis of peptide hydrazide using SPPS
- For synthesis of long or difficult peptides using peptide fragment coupling
- Native Chemical Ligation (NCL) has been one of the most used bioconjugation methodologies for synthesis of macromolecules. NCL requires a peptide thioester and another peptide moiety containing a free cysteine at the N-terminus. However, peptide thioester synthesis is technically challenging due to its instability. The use of a peptide hydrazide is more recommended.
- As a worldwide unique provider of amino acid-preloaded hydrazide resins, AnaSpec offers a series of 38 ready-to-use hydrazide resins carrying one of the 19 natural L- or D-isomer amino acids. These resins are perfectly suited for the production of activated peptide thioester via Solid Phase Peptide Synthesis (SPPS).
- All readily available resins you can find in the order section below, further hydrazide resins you can find directly at Anaspec as customized products.
- For shipping and storage information please click on Order#.
|Order#||Description||Amount||Price||Data Sheet||65534-5AS||H-Phe-hydrazide-2-CLTrt resin||5 g||479,00||65543-1AS||H-Pro-hydrazide-2-CLTrt resin||1 g||129,00||65543-5AS||H-Pro-hydrazide-2-CLTrt resin||5 g||479,00||65544-1AS||H-Ser(OtBu)-hydrazide-2-CLTrt resin||1 g||129,00||65544-5AS||H-Ser(OtBu)-hydrazide-2-CLTrt resin||5 g||479,00||65545-1AS||H-Thr(OtBu)-hydrazide-2-CLTrt resin||1 g||129,00||65545-5AS||H-Thr(OtBu)-hydrazide-2-CLTrt resin||5 g||479,00||65547-1AS||H-Trp(Boc)-hydrazide-2-CLTrt resin||1 g||129,00||65547-5AS||H-Trp(Boc)-hydrazide-2-CLTrt resin||5 g||479,00||65548-1AS||H-Tyr(OtBu)-hydrazide-2-CLTrt resin||1 g||129,00||65548-5AS||H-Tyr(OtBu)-hydrazide-2-CLTrt resin||5 g||479,00||65546-1AS||H-Val-hydrazide-2-CLTrt resin||1 g||129,00||65546-5AS||H-Val-hydrazide-2-CLTrt resin||5 g||479,00|
- All prices are in EURO excl. VAT and shipping. Only available in selected countries.
- Further hydrazide resins you can find directly at Anaspec as customized products.