Innovative Tools for Molecular and Cell Biology

Innovative Tools for Molecular and Cell Biology

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Hydrazide Resins

Amino Acid-Preloaded Hydrazide Resins for Generation of Peptide Thioester

Generation of Peptide Thioester on AA Hydrazide Resins

Generation of Peptide Thioester on AA Hydrazide Resins
A peptide hydrazide is generated after SPPS and cleavage and converted into a peptide thioester.

Bioconjugation via NCL

Bioconjugation via NCL
Generated peptide thioester can be conjugated by NCL between an unprotected C-terminal thioester peptide and a Cys/Ala-containing peptide/protein. Peptide thioesters are commonly used for bioconjugation to proteins, dyes, drugs like DOTA, or printing to glass surfaces.

Features

  • Preloaded with 19 L- & 19 D-isomer amino acids
  • For synthesis of peptide hydrazide using SPPS
  • For synthesis of long or difficult peptides using peptide fragment coupling

Description

  • Native Chemical Ligation (NCL) has been one of the most used bioconjugation methodologies for synthesis of macromolecules. NCL requires a peptide thioester and another peptide moiety containing a free cysteine at the N-terminus. However, peptide thioester synthesis is technically challenging due to its instability. The use of a peptide hydrazide is more recommended.
  • As a worldwide unique provider of amino acid-preloaded hydrazide resins, AnaSpec offers a series of 38 ready-to-use hydrazide resins carrying one of the 19 natural L- or D-isomer amino acids. These resins are perfectly suited for the production of activated peptide thioester via Solid Phase Peptide Synthesis (SPPS).

  • All readily available resins you can find in the order section below, further hydrazide resins you can find directly at Anaspec as customized products.

ORDER INFORMATION

  • For shipping and storage information please click on Order#.
Order# Description Amount Price Data Sheet
65534-5AS H-Phe-hydrazide-2-CLTrt resin 5 g 527,00 PDF
65543-1AS H-Pro-hydrazide-2-CLTrt resin 1 g 141,00 PDF
65543-5AS H-Pro-hydrazide-2-CLTrt resin 5 g 527,00 PDF
65544-1AS H-Ser(OtBu)-hydrazide-2-CLTrt resin 1 g 141,00 PDF
65544-5AS H-Ser(OtBu)-hydrazide-2-CLTrt resin 5 g 527,00 PDF
65545-1AS H-Thr(OtBu)-hydrazide-2-CLTrt resin 1 g 141,00 PDF
65545-5AS H-Thr(OtBu)-hydrazide-2-CLTrt resin 5 g 527,00 PDF
65547-1AS H-Trp(Boc)-hydrazide-2-CLTrt resin 1 g 141,00 PDF
65547-5AS H-Trp(Boc)-hydrazide-2-CLTrt resin 5 g 527,00 PDF
65548-1AS H-Tyr(OtBu)-hydrazide-2-CLTrt resin 1 g 141,00 PDF
65548-5AS H-Tyr(OtBu)-hydrazide-2-CLTrt resin 5 g 527,00 PDF
65546-1AS H-Val-hydrazide-2-CLTrt resin 1 g 141,00 PDF
65546-5AS H-Val-hydrazide-2-CLTrt resin 5 g 527,00 PDF
  • All prices are in EURO excl. VAT and shipping. Only available in selected countries.

  • Further hydrazide resins you can find directly at Anaspec as customized products.