Innovative Tools for Molecular and Cell Biology

Innovative Tools for Molecular and Cell Biology

Products

Phospholipase Research

Autotaxin (ATX) Substrate FS-3

Autotaxin (ATX) Substrate FS-3

Description

  • The fluorogenic Autotaxin (ATX) substrate FS-3 is a doubly labeled analog of LPC wherein the fluorophore is quenched through intramolecular energy transfer. Hydrolysis of the substrate produces an increase in fluorescence.

  • Autotaxin, which has lysophospholipase D (lysoPLD) activity, cleaves choline from lysophosphatidylcholine forming lysophosphatidic acid (LPA), a potent mitogen that has been implicated in the pathophysiology of ovarian cancer. LysoPLD/ATX has been demonstrated to increase cell motility, neovascularization, proliferation, and aggressiveness of tumors and is upregulated in numerous cancer lineages (non-small cell lung, glioma, mammary carcinoma, renal cell carcinoma, hepatocellular carcinoma). In addition, dysregulation of the ATX/LPA pathway is central to the pathophysiology of idiopathic pulmonary fibrosis, rheumatoid arthritis, and other inflammatory diseases. Modulation of ATX activity through small molecules is a currently underexplored target, but one with high potential for novel cancer and anti-inflammatory therapeutics.

ORDER INFORMATION

  • For shipping and storage information please click on Order#.
Order# Description Amount Price Data Sheet
L-2000-1-EC FS-3 (Lyso PLD-Autotaxin Substrate) 200 ug 535,00 PDF
L-2000-2-EC FS-3 (Lyso PLD-Autotaxin Substrate) 1 mg 2353,00 PDF
L-2000-3-EC FS-3 (Lyso PLD-Autotaxin Substrate) 100 ug 291,00 PDF
  • All prices are in EURO excl. VAT and shipping. Only available in Europe except for France and Italy.