Innovative Tools for Molecular and Cell Biology

Innovative Tools for Molecular and Cell Biology

Products

Anti-Complement Factor H ELISA

Detection of IgG Antibodies Against Complement Factor H

Vidia-Complement-Factor H-Kit

ELISA-VIDITEST: anti-complement factor H

Vidia-Comparison-of-anti-CFH-antibody-concentration

Comparison of anti-CFH antibody concentration in diseases clinically close to DEAP-HUS.
TTP = thrombotic thrombocytopenic purpura
aHUS = atypical HUS (with CFH or MCP mutation)
DEAP HUS = deficiency of CFHR plasma proteins and factor H autoantibody positive HUS
normal = plasma healthy control
Diagnosis was confirmed by genetic tests.

Features

  • First commercially available CE IVD certified ELISA for the detection of anti-CFH antibodies
  • High sensitivity/specificity
  • Quantitative evaluation of the data
  • Incubation at laboratory temperature

Description

  • ELISA-VIDITEST anti-complement factor H is intended for the quantitative detection of IgG antibodies against human complement factor H in human serum or plasma.
  • Factor H is a complement regulatory glycoprotein that is found in human plasma in concentrations of 300–800 mg/l. Autoantibodies that inhibit factor H function cause complement dysregulation, and they have been detected in about 10% of patients with atypical hemolytic uremic syndrome (aHUS). Atypical HUS is a clinical syndrome that is characterized by microangiopathic hemolytic anemia, thrombocytopenia, and renal failure.

ORDER INFORMATION

  • For shipping and storage information please click on Order#.
Order# Description Amount Price Data Sheet
ODZ-166 anti-complement factor H 48 wells 240,00 PDF
  • All prices are in EURO excl. VAT and shipping. Only available in selected countries.

Download

  • VIDIA Complement Factor H Flyer (PDF)
  • VIDIA Anti-Complement Factor H Autoantibodies Flyer (PDF)

Literature

  • Anti-factor H autoantibody-associated hemolytic uremic syndrome: review of literature of the autoimmune form of HUS. Dragon-Durey MA, Blanc C, Garnier A, Hofer J, Sethi SK, Zimmerhackl LB. Semin Thromb Hemost. 2010 Sep;36(6):633-40.
  • Anti-Factor H autoantibodies associated with atypical hemolytic uremic syndrome. Dragon-Durey MA, Loirat C, Cloarec S, Macher MA, Blouin J, Nivet H, Weiss L, Fridman WH, Frémeaux-Bacchi V. J Am Soc Nephrol. 2005 Feb;16(2):555-63.
  • Factor H autoantibodies in atypical hemolytic uremic syndrome correlate with CFHR1/CFHR3 deficiency. Józsi M, Licht C, Strobel S, Zipfel SL, Richter H, Heinen S, Zipfel PF, Skerka C.Blood. 2008 Feb 1;111(3):1512-4.