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|Liquid Biopsy. Tissue biopsies are invasive and non-feasible for longitudinal monitoring of patients; moreover, they do not capture the heterogeneity of the tissue or a disease of interest. Liquid biopsies are non-invasive and enable real time snapshot of the tissue homeostasis or alterations by detection of relevant biomarkers in the bloodstream. Tissue or disease specific exosomes and extracellular vesicles (EVs) can be isolated and analyzed from routine blood or urine samples featuring the ideal platform for biomarker discovery and clinical diagnostic development. The major challenge and opportunity in using EVs based liquid biopsy lies in the tremendous complexity of biofluid samples, heterogeneity of exosomes and extracellular vesicles and the low abundance of specific tissue or disease markers. HansaBioMed Life Sciences provides a range of pre-analytical solutions, empowered by Exosomics s.p.a, to isolate either overall EVs or selectively enrich for specific subpopulations (i.e. tumor derived-EVs) from biofluids with high yield and purity, and further extract their DNA and RNA content. Our technologies are efficient in both biomarker discovery and confirmation studies, and comply with clinical grade analytical platforms. In clinical settings, our solutions enable ultrasensitive detection of tumor associated mutations and RNA molecules, enabling next generation of tumor screening, monitoring, staging and monitoring tests. Preanalytical assay: rapid isolation of EVs from biofluids for biomarker discovery. evGAG is a patented purification method that allows isolation of extracellular vesicles (EVs) from biofluids. The evGAG reaction is based on the interaction between the precipitation solution and glycosaminoglycans (GAGs) in the EVs. The product is ideal for the discovery of EV associated biomarkers.
|HansaBioMed Life Sciences
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