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Description: Modified Nucleoside-5′-Triphosphates. Base modified NTPs have been widely used for synthesis of modified mRNA to improve stability and reduce immunogenicity. ABP Biosciences offers a list of key base modified NTPs for mRNA synthesis. Pseudo-UTP (Pseudouridine-5'-Triphosphate) is one of the most commonly used modified nucleoside-5’-O-triphosphates. Pseudo-UTP is a building block for the polymerase-mediated synthesis of RNA molecules. RNA molecules, especially messenger RNAs (mRNAs), have widespread applications in therapeutic and diagnostic areas, and have demonstrated their superiority over plasmid DNA techniques in both gene and vaccination therapy. Compared with uridine-containing unmodified mRNAs, the application of pseudouridine-containing modified mRNAs exhibits better nuclease stability, immunogenicity, and translational properties. Thus, pseudo-UTP could be used to develop drugable mRNAs with improved properties, by replacing the standard bases by modified ones.
Order #: LP010-2-ABP
Unit Size: 50 µL
Supplier: ABP Biosciences
Shipping: Ice Pack
Storage: -20°C
Subcategory: Nucleotides
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