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anti-VCA EBV IgM ELISA (semiquant.)

anti-VCA EBV IgM ELISA (semiquant.)
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Description: Herpesviruses: Epstein-Barr Virus – EBV: ELISA-VIDITEST anti-EBV and IF-VIDITEST anti-EBV kits are intended for the diagnosis of EBV-associated diseases, i.e. infectious mononucleosis, chronic active EBV infection, EBV-related lymphoproliferative disorders and nasopharyngeal carcinoma. The tests can also contribute to laboratory examination of immune deficiency syndromes, chronic fatigue syndrome and other conditions when reactivation of latent EBV infection is common. Markers of EBV infection: Viral capsid antigen – VCA: structural protein or protein complex, the compound of the viral capsid • EB-viral nuclear antigen 1 – EBNA-1: nonstructural nuclear protein, present in latently infected cells • Early antigen – EA: nonstructural protein or protein complex, synthetized in early phase of viral replication cycle. Based on the structure and localization in the infected cells, two components of EA can be distinguished. EA-R (restricted) component is present in distinct regions of cytoplasm and methanol-resistant EA-D (diffuse) component is dispersed both in the cytoplasm and in the nucleus. Kits for the Detection of Antibodies to EBV Viral Capsid Antigen – VCA: IgG antibodies have anamnestic character and persist in infected individual for a life. Seroconversion can be detected in early acute phase of the primary infection. Significant rise in IgG anti-VCA antibody indicate reinfection or reactivation. Avidity determination enables differentiation between primary and past infection or reactivation. IgM and IgA antibody response is typical for active infection. High levels of IgM anti-VCA are usually present in acute and convalescent phase of infectious mononucleosis (IM), while in EBV reactivation IgM response is low and often undetectable and IgA response is more pronounced. After recovery, both IgM and IgA may persist for several weeks or months. CE-IVD certified.
Order #: ODZ-005
Unit Size: 96 wells
Supplier: VIDIA
Shipping: Blue Ice
Storage: 4 °C
Subcategory: Infectious Serology
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