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anti-EA (D) EBV IgA ELISA (semiquant.)

anti-EA (D) EBV IgA ELISA (semiquant.)
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Description: Herpesviruses: Epstein-Barr Virus – EBV: ELISA-VIDITEST anti-EBV and IF-VIDITEST anti-EBV kits are intended for the diagnosis of EBV-associated diseases, i.e. infectious mononucleosis, chronic active EBV infection, EBV-related lymphoproliferative disorders and nasopharyngeal carcinoma. The tests can also contribute to laboratory examination of immune deficiency syndromes, chronic fatigue syndrome and other conditions when reactivation of latent EBV infection is common. Markers of EBV infection: Viral capsid antigen – VCA: structural protein or protein complex, the compound of the viral capsid • EB-viral nuclear antigen 1 – EBNA-1: nonstructural nuclear protein, present in latently infected cells • Early antigen – EA: nonstructural protein or protein complex, synthetized in early phase of viral replication cycle. Based on the structure and localization in the infected cells, two components of EA can be distinguished. EA-R (restricted) component is present in distinct regions of cytoplasm and methanol-resistant EA-D (diffuse) component is dispersed both in the cytoplasm and in the nucleus. Kits for the Detection of Antibodies to EBV Early Antigen – EA: Anti-EA IgG and IgM is a supplemental marker of EBV activation (both primary infection and reactivation). High titers of anti-EA(D) are typical for late acute and convalescence phase of infectious mononucleosis, while anti-EA(R) is more frequent marker of EBV reactivation. In chronic reactivation and chronic active EBV infection antibody response against both the components can be found. High titers of IgG and IgA anti-EA(D) are observed in patients with nasopharyngeal carcinoma, the latter having prognostic significance. High levels of anti- EA(R) are characteristic for patients with EBV associated Burkitt lymphoma. CE-IVD certified.
Order #: ODZ-254
Unit Size: 96 wells
Supplier: VIDIA
Shipping: Blue Ice
Storage: 4 °C
Subcategory: Infectious Serology
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