|Description:||Echelon's Lysosomal Phospholipase A2 (LPLA2) Activity Assay is a homogenous assay designed to detect activity from biological and purified sources of LPLA2. This (in vitro, )plate-basedassay uses a quenched substrate which fluoresces when hydrolyzed by LPLA2. The (sn-1)position of the quenched substrate is protected by an amine group to eliminate non-specific turnover by phospholipase A1. The acidic assay conditions further improve selectivity of LPLA2 for hydrolysis of the quenched substrate. This direct biochemical approach provides a specific, quantitative measurement in a robust and easy-to-use format for measurement of LPLA2 activity Background Human LPLA2, also known as Lp-PLA2 or PLA2G15, is an enzyme responsible for normal lipid metabolism and is unique from other known PLA2s. LPLA2 is only active in acidic environments and research suggests it is related to drug-induced phospholipidosis (DIPL). DIPL is a condition of excessive accumulation of intracellular phospholipids triggered by long-term use of certain cationic amphiphilic drugs (CADs) such as fluoxetine (Prozac, Sarafem) and Amiodarone. DIPL results in tissue inflammation and organ damage. If not treated, DIPL can be fatal. The FDA has determined that DIPL is a serious drug safety issue. Storage: -20°C. Avoid frequent freeze-thaw cycles.|
|Unit Size:||EA KIT|
|Restrictions:||Available in all European countries, except France & Italy.|
|Shipping:||Dry Ice Or Gel Ice Depending On Destination|
|Subcategory:||Kits & Assays|
|More information:||Go to webpage|
*All prices are net in Euro and do not include applicable taxes, shipping & handling, or other charges (e.g., customs duties).
Delivery time approx. 8 - 10 working days
- Phone: +49 (0)551 707 22 70
- E-mail: firstname.lastname@example.org
How To Order
Orders can be placed by phone, fax, e-mail, or via our online shop:
After placing your order, you will receive an order confirmation via e-mail within 2 working days. If you do not receive this e-mail, please contact us by phone. Thank you! More information regarding our ordering process can be found here.