SensoLyte® Green Pin1 Assay Kit *Fluorimetric*

Description:	Peptidyl-prolyl isomerase (PPIase) Pin1 catalyzes cis/trans isomerization of the phospho-Serine/Threonine-Proline peptide bonds (1-5). Pin1 consists of short N-terminal protein-protein interaction domain that allowsEnzyme to bind phosphoproteins and longer C-terminal izomerase domain (1-5). Pin1 has many biological substrates, plays critical role in cell-cycle regulation, and up-regulated in many humanCancers (1-5). Recently, Pin1 was linked to the Alzheimer’s disease pathogenesis (1, 2, 4). Pin1 can bind phosphorylated Thr-212/231 residues of Tau protein and increase its deposphorylation that may prevent formation of Tau neurofibrilary tangles (1, 2, 4). The SensoLyte® Green Pin1 Assay Kit uses a fluorogenic substrate in the cis isoform. Pin1 changes substrate into trans conformation, which is then readily cleaved to generate fluorescent signal which can be monitored at Ex/Em=490/520nm. Increase in fluorescence intensity is directly proportional to the Pin1 activity.
Order #:	AS-72240
Unit Size:	1 kit
Supplier:	AnaSpec
Restrictions:	Only available in Germany and selected European countries.
Shipping:	Dry Ice
Storage:	Component B at -80 °C, all other components at -20 °C
Subcategory:	Enzyme Assays
More information:	Go to webpage

Datasheet

501.00 € *

*All prices are net in Euro and do not include applicable taxes, shipping & handling, or other charges (e.g., customs duties).

Delivery time approx. 8 - 10 working days

How To Order

Orders can be placed by phone, fax, e-mail, or via our online shop:

Phone: +49 551 707 220
Fax: +49 551 707 2222
E-mail: info@mobitec.com
Online Shop: www.mobitec.com

After placing your order, you will receive an order confirmation via e-mail within 2 working days. If you do not receive this e-mail, please contact us by phone. Thank you! More information regarding our ordering process can be found here.

Technical Service - Product Information

Phone: +49 (0)551 707 22 70
E-mail: info@mobitec.com