mobitec-globe Innovative Tools for Molecular and Cell Biology

SensoLyte® 520 Meprin ß Activity Assay Kit Fluorimetric - 1 kit

SensoLyte® 520 Meprin ß Activity Assay Kit Fluorimetric - 1 kit
Usage: hover your mouse-pointer anywhere on the image above to see an enlarged portion of the image. You can also just click the image to see the original-sized version.
Description: Meprin β, a type I transmembrane metalloprotease, belongs to the astacin family of zinc endopepdidases and the metzincin superfamily. Protein expression had been identified in multiple tissues and cell types such as kidney, intestine, skin, leukocytes and several cancer cells. Though the biological function of Meprin β is not fully understood, it was found that Meprin β plays various roles in inflammatory response, collagen assembly, cancer progression and β-amyloid protein cleavage. More growing evidence has indicated that Meprin β is a good therapeutic target in regulating angiogenesis, cancer, inflammation, fibrosis, and neurodegenerative diseases. The SensoLyte® 520 Meprin β Activity Assay Kit can be used to detect enzyme activity in purified enzyme preparations and compound screening. The unique FRET substrate was derived from APP sequence designed to reduce the cross reactivity with Meprin a, ADAM10, β?secretase, BACE-2, IDE and ECEs, Neprilysin and TACE. Active Meprin β cleaves the FRET substrate resulting in an increase of 5-FAM fluorescence, that can be monitored at excitation/emission = 490 nm/520 nm. The long wavelength fluorescence of 5-FAM is also less interfered by the autofluorescence of components in biological samples and test compounds. This assay can detect as low as 0.048 ng/mL active Meprin β.
Order #: AS-72254
Unit Size: 1 kit
Supplier: AnaSpec
Restrictions: Only available in Germany and selected European countries.
Shipping: Dry Ice
Storage: - 78 °C
Subcategory: Enzyme Assay Kits
More information: Go to webpage
Datasheet Flyer or Brochure
607.00 € *

*All prices are net in Euro and do not include applicable taxes, shipping & handling, or other charges (e.g., customs duties).

Delivery time approx. 8 - 10 working days

    How To Order

    Orders can be placed by phone, fax, e-mail, or via our online shop:

    After placing your order, you will receive an order confirmation via e-mail within 2 working days. If you do not receive this e-mail, please contact us by phone. Thank you! More information regarding our ordering process can be found here.

    Technical Service - Product Information