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SensoLyte® Rh110 Furin Activity Assay Kit *Fluorimetric*

SensoLyte® Rh110 Furin Activity Assay Kit *Fluorimetric*
Description: Furin is a serine protease that belongs to the subtilisin-like proprotein convertase (PC) family. Furin catalyzes the proteolytic maturation of proprotein substrates in the secretory pathway. Furin plays an essential role in embryogenesis and homeostasis, as well as in diseases ranging from Alzheimer's disease, cancer, anthrax, to Ebola fever. Furin is essential to the maturation and viral infectivity of HIV. Furin is a potential target for drug design, especially for the inhibition of furin-dependent virus replication. The SensoLyte® Rh110 Furin Assay Kit provides a convenient assay for screening of enzyme inhibitors or for continuous assay of furin activity using a fluorogenic substrate. Upon cleavage by furin, this substrate generates the Rh110 (rhodamine 110) fluorophore with bright green fluorescence that can be detected at excitation/emission=490 nm/520 nm. The longer-wavelength spectra and higher extinction coefficient of the Rh110 provide greater sensitivity and less interference from other reaction components. The detection limit can reach as low as 0.02 ng/mL.
Order #: AS-72256
Unit Size: 1 kit
Supplier: AnaSpec
Restrictions: Only available in Germany and selected European countries.
Shipping: Dry Ice
Storage: Component C at -80 °C, all other components at -20 °C
Subcategory: Enzyme Assays
More information: Go to webpage
Datasheet
457.00 € *

*All prices are net in Euro and do not include applicable taxes, shipping & handling, or other charges (e.g., customs duties).

Delivery time approx. 8 - 10 days

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