mobitec-globe Innovative Tools for Molecular and Cell Biology

PrP (106-126), prion protein - 1 mg

PrP (106-126), prion protein - 1 mg
Usage: hover your mouse-pointer anywhere on the image above to see an enlarged portion of the image. You can also just click the image to see the original-sized version.
Description: Prion protein (PrP), also known as CD230, is mainly produced in the nervous sytem. PrP exists as different isoforms, among which the normal PrPc, and the 'scrapie' isoform PrPSc. PrPSc is misfolded and associated to multiple disorders including bovine spongiform encephalopathy, Gerstmann-Straüssler-Scheindker disease (GSS) and the Creutzfeldt-Jakob disease. It contains a much higher beta-sheet content than PrPc, and tends to form protease-resistant aggregates. A hypothesis to support the propoagation of these aggregates and their role in neurodegeneration is the change from normal PrPc to PrPSc triggered by its interaction with PrPSc (conformation conversion hypothesis). PrP 127-147 forms filamentous structures ressembling scrapie-associated fibrils, but possesses a lower amyloidogenic potential than PrP 106-126. This peptide increases membrane microviscosity, intracellular Ca2+ concentration and cell migration in circulating leucocytes, and oxygen production in monocytes and neutrophils. It also induces apoptotic cell death and impairment of L-type voltage-sensitive calcium channel activity in the GH3 cell lines. PrP (106–126) stimulates leucocyte migration in a dose-dependent manner.
Order #: AS-61160
Unit Size: 1 mg
Supplier: AnaSpec
Restrictions: Only available in Germany and selected European countries.
Shipping: RT
Storage: - 20 °C
Subcategory: Peptides
More information: Go to webpage
Datasheet Flyer or Brochure
Add to request list
    Technical Service - Product Information

    MoBiTec is now part of BIOZOL

    All products can now be ordered via BIOZOL. For price information please use the Add to request list button or visit the BIOZOL webpage.