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|Protease activated receptor 1 (PAR-1) belongs to a subfamily of G-protein coupled receptors and is known to mediate the cellular effects of thrombin. This protease-activated receptor-1 (PAR-1) selective peptide induces cyclooxygenase-2 (COX-2) protein and mRNA expression in human endothelial cells. Studies show that intratracheal instillation of the PAR1-specific peptide increases lung edema during high-tidal-volume ventilation
|Only available in Germany and selected European countries.
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