mobitec-globe Innovative Tools for Molecular and Cell Biology

Renin FRET Substrate (5-FAM/QXL™520) - 0.1 mg

Renin FRET Substrate (5-FAM/QXL™520) - 0.1 mg
Usage: hover your mouse-pointer anywhere on the image above to see an enlarged portion of the image. You can also just click the image to see the original-sized version.
Description: This FRET peptide is a specific substrate for renin. Aspartyl protease cleaves angiotensinogen to yield angiotensin I, which is further converted to angiotensin II. The renin-angiotensin system is a coordinated hormonal cascade in the control of cardiovascular, renal, and adrenal function. It governs body fluid and electrolyte balance, as well as arterial pressure. Since an overactive renin-angiotensin system leads to hypertension, renin is an attractive target for the treatment of this disease. This renin peptide substrate may be used for screening of renin inhibitors. In the FRET peptide, the fluorescence of 5-FAM is quenched by QXL® 520. Upon cleavage into two separate fragments by renin, the fluorescence of 5-FAM is recovered, and can be monitored at excitation/emission = 490/520 nm. This substrate is employed in the SensoLyte® 520 Renin Assay Kit, cat # AS-72040.
Order #: AS-61872-01
Unit Size: 0.1 mg
Supplier: AnaSpec
Restrictions: Only available in Germany and selected European countries.
Shipping: RT
Storage: - 20 °C Darkness
Subcategory: Peptides
More information: Go to webpage
Datasheet Flyer or Brochure
Add to request list
    Technical Service - Product Information

    MoBiTec is now part of BIOZOL

    All products can now be ordered via BIOZOL. For price information please use the Add to request list button or visit the BIOZOL webpage.

Viewed