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|Several mutations in the beta amyloid precursor gene cause autosomal dominant Alzheimer's Disease in a number of kindreds. The Dutch/Iowa mutant beta-amyloid rapidly assembles in solution to form fibrils. This double-mutant E22Q/D23N Dutch/Iowa beta-Amyloid 40 is more potent than either of the single mutant forms in causing pathologic responses in culture cells. The double mutation further enhances the fibrillogenic and pathogenic properties of beta-Amyloid.
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