|Description:||Several mutations in the beta amyloid precursor gene cause autosomal dominant Alzheimer's Disease in a number of kindreds. Among them, the Italian mutation (E22K) leads to beta-amyloid peptides which aggregate more rapidly and exhibit potent neurotoxicity compared to wild-type beta-amyloid 1-40. The formation of a salt bridge between Lys-22 and Asp-23 in the minor conformer might explain why E22K-beta-amyloid 1-40 is more pathogenic than its wild-type conterpart.|
|Unit Size:||0.5 mg|
|Restrictions:||Only available in Germany and selected European countries.|
|Storage:||- 20 °C|
|More information:||Go to webpage|
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