|Description:||Programed cell death 1 (PD-1) receptor and its ligand PD-L1 are crucial immune checkpoints to downregulate T cell activation, tolerance and immunopathology. Several types of cancer cells were identified to overexpress PD-L1 so as to escape from the PD-1/PD-L1 immunosurveillance mechanism. This peptide, hPDL-1 inhibitor II binds to human PD-1 and inhibits PD-1/PD-L1 binding. It has anchor residues, WDY that show a great impact on the binding of hPD-L1 to hPD-1. Developing molecules specifically blocking the PD-1/PD-L1 pathway has become popular approach to cancer treatment.|
|Unit Size:||1 mg|
|Restrictions:||Only available in Germany and selected European countries.|
|Storage:||- 20 °C|
|More information:||Go to webpage|
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