AmpliSens® HPV HCR screen-titre-14-FRT PCR kit variant FRT-100 FN (Ecoli Dx Product Code: H-2311-1-13-CE)
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| Description: | High-Risk HPV Infections - Human papillomaviruses (HPVs) are a group of more than 150 related viruses. They are called papillomaviruses because certain types may cause warts, or papillomas, which are benign (noncancerous) tumors. Some HPVs, such as those that cause common warts that grow on hands and feet, do not spread easily. However, more than 40 HPV types are sexually transmitted and these HPVs spread very easily through genital contact. Some types of sexually transmitted HPVs cause cervical cancer and other types of cancer. These are called high-risk, oncogenic, or carcinogenic HCR HPVs - (about 13 types). Other sexually transmitted types of HPV do not appear to cause cancer and are called low-risk HPVs (LCR HPVs). Although genital HPV infections are very common, most occur without any symptoms and go away without any treatment within a few years. However, some HPV infections can persist for many years. Persistent infections with high-risk HPV types can cause cell abnormalities. If untreated, areas of abnormal cells (lesions) can in some cases develop into cancer. Some types of sexually transmitted low-risk HPVs cause warts to appear on or around the genitals or anus. Most genital warts are caused by two HPV types, HPV-6 and HPV-11. Warts may appear within several weeks after sexual contact with a person who is infected with HPV, or they may take months or years to appear, or they may never appear. AmpliSens HPV HCR screen-titre-14-FRT PCR kit is an in vitro nucleic acid amplification test for quantitative detection of DNA of human papillomaviruses of high carcinogenic risk (HPV HCR) genotypes 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68 in the clinical material (vaginal swab, epithelial scrape from the cervical mucous membrane (ectocervix and endocervix)) using real-time hybridization-fluorescence detection of amplified products. PCR kit allows to separately identify the HPV DNA of genotypes 16, 18 and 45. HPV HCR are the main etiological factor in the development of cervical cancer and the previous high grade dysplasia. HPV is detected in 95 % of all cervical cancer cases. The specified genotypes 16, 18 and 45 in conjunction are known to cause around 75% squamous cell carcinomas and 94% cervical adenocarcinoma cases. The PCR kit allows to determine the total number of HPV DNA of all 14 genotypes and also to separately identify the HPV DNA of 16, 18 and 45 genotypes. It is known that development of cervical cancer is often associated with integration of viral DNA into the genome of the host cell. HPV of genotypes 16 and 18 integrate the most frequently, while the Е1/Е2 region is being broken and Е6/Е7 oncogene persists. The AmpliSens HPV HCR screen-titre-14-FRT PCR kit has been developed to detect different genome section of HPV types 16, 18 and 45 in the different channels of the instrument. Detection of E6 region (in the absence of Е1/Е2 region) allows indirectly to judge about the possibility of virus integration into the human genome. |
| Order #: | ECO-H-2311-1-13-CE |
| Unit Size: | 110 |
| Supplier: | Ecoli Dx |
| Restrictions: | Only available in selected countries. |
| Shipping: | See Manual |
| Storage: | See Manual |
| Subcategory: | PCR and Real-Time PCR Diagnostics |
| More information: | Go to webpage |
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