UBPBio: Accelerate Discoveries on the Ubiquitin-Proteasome System and Related Pathways

Ubiquitin-Proteasome System

The ubiquitin proteasome system (UPS) degrades individual proteins in a highly regulated fashion and is responsible for the degradation of misfolded, damaged, or unneeded cellular proteins. The UPS plays a critical role in essentially every cellular process, including cell cycle progression, transcriptional regulation, genome integrity, apoptosis, immune responses, and neuronal plasticity. At the center of the UPS is the proteasome, a large and complex molecular machine containing a multicatalytic protease complex. When the efficiency of this proteostasis system is perturbed, misfolded and damaged protein aggregates can accumulate to toxic levels and cause neuronal dysfunction, which may underlie many neurodegenerative diseases. In addition, many cancers rely on robust proteasome activity for degrading tumor suppressors and cell cycle checkpoint inhibitors necessary for rapid cell division.

Cover the ubiquitin-proteasome system, cell death/survival pathways, autophagy pathway, inflammatory pathways, etc. with UBPBio’s unique product portfolio:

• Proteasomes / Activators / Subunits
• E1 Activating Enzymes
• E2 Conjugating Enzymes
• E3 Ubiquitin Ligases
• Ubiquitin / SUMO Chains
• Ubiquitin / Ubiquitin-like Proteins / Mutants
• Deubiquitinating Enzymes
• Ubiquitin / UBL Derivatives
• Proteasome / Deubiquitinase Inhibitors
• Fluorescent Peptide / Protein Substrates
• Ubiquitin Binding Proteins
• Antibodies
• Kits
• Protein Expression / Purification Reagents
• DNA/Protein Ladders