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Antimicrobial Peptides in Host Defense

Antimicrobial Peptides Represent a Promising Therapeutic Approach in the Post-Antibiotics Era

Antimicrobial peptides (AMPs), also referred to as host defense peptides, are short peptides found in a wide variety of life forms from microorganisms to humans. Many AMPs exhibit an extraordinarily broad range of antimicrobial activity covering both Gram-positive and Gram-negative bacteria as well as fungi, enveloped viruses, and unicellular protozoa. AMPs or their optimized derivatives

  • can be used as broad-spectrum antibiotics
  • display a rapid killing ability
  • are effective against multi-drug-resistant bacteria
  • inhibit biofilm formation or reduce/eradicate mature biofilms
  • show a complex, often multimodal antimicrobial action which makes it difficult for microbes to develop durable resistance mechanisms

AnaSpec offers a comprehensive range of AMPs, including inhibitors of biofilms, mammalian defensins, cathelicidins, magainins, etc:

Diverse Antimicrobial Peptides

Biofilm Inhibitors

Mammalian Defensins

  • hBD-1, b-Defensin-1, human AS-60740
  • hBD-3, b-Defensin 3 (hBD3) Derivative, human (CHRG01) AS-64886
  • hBD - 3, β - Defensin - 3, human AS-60741
  • HNP - 1, Defensin Human Neutrophil Peptide – 1 AS-60743
  • HNP - 2, Defensin Human Neutrophil Peptide – 2 AS-60744