Description: | MDM2 is an E3 ubiquitin ligase that targets the p53 protein for proteasomal degradation. Akt-mediated phosphorylation of MDM2 at Ser166 and Ser186 increases its interaction with p300, allowing MDM2-mediated ubiquitination and degradation of p53. Phosphorylation of MDM2 also blocks its binding to p19ARF, increasing the degradation of p53. |
Order #: | UBP-Y8002-100-100 |
Unit Size: | 100 µl |
Supplier: | UBPBio |
Restrictions: | Only available in selected countries. |
Shipping: | Wet ice |
Storage: | -20 °C |
Subcategory: | E3 Ub Ligases |
More information: | Go to webpage |
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