Green GENIe cGMP Sensor
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| Description: | Monitor cGMP production or phosphodiesterase inhibition in living cells ‖ PDE Biology: Cyclic nucleotide phosphodiesterases (PDEs) are important drug targets with unique tissue distribution and functional properties. This family of enzymes is key in the regulation of cyclic nucleotide second messenger levels because they degrade both cAMP and cGMP. Some PDEs hydrolyze both cAMP and cGMP, while others are either cAMP or cGMP hydrolases. Selective PDE inhibitors block the activity of specific PDEs and are used to treat a variety of diseases. Non-selective PDE inhibitors include IBMX and caffeine, both of which are important consumables in basic research laboratories. Montana Molecular tools for PDE Biology: Detect changes in intracellular cAMP and cGMP • Screen for PDE Inhibitors • Determine PDE selectivity • Monitor PDE Rates using Optogenetics • BacMam-mediated expression in disease relevant cell types • Detect fluorescence changes with automated plate readers and imaging systems |
| Order #: | D0800G-010 |
| Unit Size: | 10 ml Kit |
| Supplier: | Montana Molecular |
| Restrictions: | Available in all European countries. |
| Shipping: | Cool Pack |
| Storage: | 4 °C |
| Subcategory: | Cell Signaling |
| More information: | Go to webpage |
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