Sphingosine 1-Phosphate Lyase Overexpression Lysate, active (Echelon Product Code: E-5000L 250UG)
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| Description: | HEK293 cell lysate with overexpressed SPL-GFP (green fluorescent protein). Storage: -80°C. The enzyme is stable for 6 months from the date of receipt. Avoid repeat freeze thaw cycles. Product Description Sphingsoine 1-phosphate lyase (SPL) (E.C.4.1.2.27) works as a key regulator of the final step of the sphingolipid degradative pathway by irreversibly breaking down the sphingosine-1-phosphate (S1P) to ethanolamine phosphate and hexadecenal. S1P signaling through its five receptors involves in many biological events such as proliferation, inflammation and apoptosis in cancer and other degenerative diseases. A support protocol for detection of S1P lyase activity is available below. » References 1. Billich, A., et al. (2013). "Partial deficiency of sphingosine-1-phosphate lyase confers protection in experimental autoimmune encephalomyelitis." PLoS One 8(3): e59630. 2. Engel, N., et al. (2012). Metabolic profiling reveals sphingosine-1-phosphate kinase 2 and lyase as key targets of (phyto-) estrogen action in the breast cancer cell line MCF-7 and not in MCF-12A." PLoS One 7(10): e47833. 3. Bedia, C., et al. (2009). "Synthesis of a fluorogenic analogue of sphingosine-1-phosphate and its use to determine sphingosine-1-phosphate lyase activity." Chembiochem 10(5): 820-2. 4. Reiss, U., et al. (2004) "Sphingosine-phosphate Lyase Enhances Stress-induced Ceramide Generation and Apoptosis." J. Biol. Chem. 279(2): 1281-1290. |
| Order #: | ECH-E-5000L-250UG |
| Unit Size: | 250 ug |
| Supplier: | Echelon Biosciences |
| Restrictions: | Available in all European countries, except France & Italy. |
| Shipping: | Dry Ice |
| Storage: | -80 °C or below |
| Subcategory: | Antibodies & Proteins |
| More information: | Go to webpage |
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