INPP4A, active (Echelon Product Code: E-8000 2.5UG)
| Description: | Human INPP4A with N-terminal 6-His tag Storage: Store product -70 °C. Enzyme is stable for at least 6 months at -70 °C as undiluted stock Specificity: INPP4 selectively removes the phosphate from the 4" position of the inositol ring of PtdIns(3, 4)P2 Molecular Weight: 107 kDa Specific Activity: request Certificate of Analysis (COA) Product Description Human INPP4A with N-terminal 6-His tag was expressed in Sf9 cells and purified using metal chelating chromatography. INPP4A is a magnesium-independent phosphatase involved in the phosphatidylinositol 3-kinase (PI3K) pathway. INPP4A and its isoenzyme INPP4B hydrolyze the 4 phosphate from the lipid second messenger phosphatidylinositol-3, 4-bisphosphate (PI(3, 4)P2) to form phosphatidylinositol-3-phosphate (PI(3)P). While little evidence supports its role as a tumor suppressor, INPP4A does suppress glutamate excitotoxicity in the central nervous system and is responsible for the Weeble mouse phenotype. A spontaneous frame shift mutation in the Inpp4a gene is present in the Weeble mouse resulting in selective neuronal loss in the cerebellum resulting, severe ataxia and early death. |
| Order #: | ECH-E-8000-2.5UG |
| Unit Size: | 2.5 ug |
| Supplier: | Echelon Biosciences |
| Restrictions: | Available in all European countries, except France & Italy. |
| Shipping: | Dry Ice |
| Storage: | -80 °C or below |
| Subcategory: | Antibodies & Proteins |
| More information: | Go to webpage |
336.00 € *
*All prices are net in Euro and do not include applicable taxes, shipping & handling, or other charges (e.g., customs duties).
Delivery time approx. 8 - 10 working days
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