PI4-Kinase beta (PI4Kb), active (Echelon Product Code: P32-102G 5UG)
| Description: | PI4-Kinase beta (PI4Kb), active is a full-length, recombinant human PI4KB co-expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. Enzyme obtained from SignalChem. Molecular weight: ~120 kDa Sequence: Full length Species: Human Tag: GST tag Purity: 90 % (request TDS for lot specific information) Specific Activity: 30 nmol/min/mg (request TDS for lot specific information) Expression System: Sf9 insect cells using baculovirus Genebank Number: BC000029; Applications: PI 4-Kinase assay; , western blot. Formulation: Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol. Storage and stability: Store product at -70°C. Stable up to one year. Product Background PI4KB is a member of the phosphatidylinositol 4-kinase family (PI4K) and is the first committed step in the production of the second messenger inositol-1, 4, 5-trisphosphate (PIP3). PI4KB regulates the golgi disintegration/reorganization during mitosis possibly via the phosphorylation of phosphatidylinositol. PI4KB is a type III enzyme that is sensitive to wortmannin and is responsible for regulating the synthesis of agonist-sensitive pools of polyphosphoinositides. PI4KB is critical for glucose-induced insulin secretion due to its capacity to regulate the release of secretory granules. PI4KB inhibits the insulin-stimulated translocation of glucose transporter-4 in mouse adipocytes through its interaction with neuronal calcium sensor. |
| Order #: | ECH-P32-102G-5UG |
| Unit Size: | 5 ug |
| Supplier: | Echelon Biosciences |
| Restrictions: | Available in all European countries, except France & Italy. |
| Shipping: | Dry Ice |
| Storage: | -20 °C or below |
| Subcategory: | Antibodies & Proteins |
| More information: | Go to webpage |
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