Biotinylated Anti-PtdIns(4, 5)P2 IgM (Echelon Product Code: Z-B045 10UG)
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| Description: | Purified Anti-PtdIns(4, 5)P2 monoclonal antibody conjugated with biotin. Subclass: IgM Source: Mouse Applications: ELISA, Immunofluorescence, Protein-Lipid Overlay (PIP Strip), Flow Cytometry Product Background: Phosphoinositides (PIP(n)s) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4, 5-bisphosphate (PIP2) has been shown to play a central role in a variety of cellular functions. Amongst its many functions, PIP2 is a substrate for Phospholipase C-coupled G-protein pathways involved in intracellular calcium release in a number of tissues. It is also a substrate for class I phosphoinositide 3-kinase (PI3-K) forming PIP3. Storage 2-8 °C for up to 30 days, -20 °C for greater than 30 days. Do not freeze thaw multiple times; Featured in Publications 1) Hoek, K. L., P. Antony, et al. (2006). "Transitional B cell fate is associated with developmental stage-specific regulation of diacylglycerol and calcium signaling upon B cell receptor engagement." J Immunol 177(8): 5405-13. 2) Antony, P., K. Hoek, et al. (2007). µMicro-scale flow cytometry-based and biochemical analysis of lipid signaling in primary B cell subpopulations." Biol Proced Online 9: 73-83. 3) Marquez, M. G., C. Fernandez-Tome Mdel, et al. (2009). "Bradykinin induces formation of vesicle-like structures containing vinculin and PtdIns(4, 5)P2 in renal papillary collecting duct cells." Am J Physiol Renal Physiol 297(5): F1181-91. |
| Order #: | ECH-Z-B045-10UG |
| Unit Size: | 10 ug |
| Supplier: | Echelon Biosciences |
| Restrictions: | Available in all European countries, except France & Italy. |
| Shipping: | Dry Ice |
| Storage: | -20 °C or below |
| Subcategory: | Antibodies & Proteins |
| More information: | Go to webpage |
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