Fluorescein conjugated Anti-PI(3, 4, 5)P3 IgM (Echelon Product Code: Z-G345 250UG)
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| Description: | Purified Anti-PtdIns(3, 4, 5)P3 monoclonal antibody conjugated with fluorescein. Subclass: IgM Source: Mouse Applications: ELISA, Immunofluorescence Product Background:Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3, 4, 5-trisphosphate (PIP3), formed from PI(4, 5)P2 though phosphorylation by PI 3-kinase, activates numerous signaling pathways resulting in cell proliferation, growth, survival, glucose transport and protein synthesis. High PIP3 levels from disregulation of PI3-K have been demonstrated in cancer and inflammatory diseases. PIP3 is hydrolyzed by the phosphatases PTEN to PI(4, 5)P2 and SHIP to PI(3, 4)P2. Storage Protect from light. 2-8 °C for up to 30 days, -20 °C for greater than 30 days. Do not freeze thaw multiple times. Featured in Publications 1) Vedham, V., H. Phee, et al. (2005). "Vav activation and function as a rac guanine nucleotide exchange factor in macrophage colony-stimulating factor-induced macrophage chemotaxis." Mol Cell Biol 25(10): 4211-20. 2) Gupta, S., A. R. Ramjaun, et al. (2007). "Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice." Cell 129(5): 957-68. 3) Lin, H. V., L. Plum, et al. (2010). "Divergent Regulation of Energy Expenditure and Hepatic Glucose Production by Insulin Receptor in Agouti-Related Protein and POMC Neurons." Diabetes 59(2): 337-346. |
| Order #: | ECH-Z-G345-250UG |
| Unit Size: | 250 ug |
| Supplier: | Echelon Biosciences |
| Restrictions: | Available in all European countries, except France & Italy. |
| Shipping: | Dry Ice |
| Storage: | -20 °C or below |
| Subcategory: | Antibodies & Proteins |
| More information: | Go to webpage |
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