Purified Anti-PtdIns(3, 4, 5)P3 IgM (Echelon Product Code: Z-P345 250UG)
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| Description: | Purified Anti-PtdIns(3, 4, 5)P3 monoclonal antibody. Subclass: IgM Source: Mouse Applications: ELISA, Immunofluorescence Product Background: Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3, 4, 5-trisphosphate (PIP3), formed from PI(4, 5)P2 though phosphorylation by PI 3-kinase, activates numerous signaling pathways resulting in cell proliferation, growth, survival, glucose transport and protein synthesis. High PIP3 levels from disregulation of PI3-K have been demonstrated in cancer and inflammatory diseases. PIP3 is hydrolyzed by the phosphatases PTEN to PI(4, 5)P2 and SHIP to PI(3, 4)P2. Storage 2-8 °C for up to 30 days, -20 °C for greater than 30 days. Do not freeze thaw multiple times. Featured in Publications 1) Chen, R., V. H. Kang, et al. (2002). "A monoclonal antibody to visualize PtdIns(3, 4, 5)P(3) in cells." J Histochem Cytochem 50(5): 697-708. 2) Weiner, O. D., P. O. Neilsen, et al. (2002). "A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity." Nat Cell Biol 4(7): 509-13. 3) Silva, A., J. A. Yunes, et al. (2008). "PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability." J Clin Invest 118(11): 3762-74. 4) Shearn, C. T., R. L. Smathers, et al. (2011). "Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibition by 4-hydroxynonenal leads to increased Akt activation in hepatocytes." Mol Pharmacol 79(6): 941-52. |
| Order #: | ECH-Z-P345-250UG |
| Unit Size: | 250 ug |
| Supplier: | Echelon Biosciences |
| Restrictions: | Available in all European countries, except France & Italy. |
| Shipping: | Dry Ice |
| Storage: | -20 °C or below |
| Subcategory: | Antibodies & Proteins |
| More information: | Go to webpage |
948.00 € *
*All prices are net in Euro and do not include applicable taxes, shipping & handling, or other charges (e.g., customs duties).
Delivery time approx. 8 - 10 working days
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