Purified Anti-PtdIns(3, 4, 5)P3 IgG (Echelon Product Code: Z-P345B 250UG)
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| Description: | Purified Anti-PtdIns(3, 4, 5)P3 monoclonal antibody. Subclass: IgG1 Source: Mouse Applications: ELISA, Alphascreen, Fluorescence Polarization, Protein-Lipid Overlay (PIP Strip) Product Background: Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3, 4, 5-trisphosphate (PIP3), formed from PI(4, 5)P2 though phosphorylation by PI 3-kinase, activates numerous signaling pathways resulting in cell proliferation, growth, survival, glucose transport and protein synthesis. High PIP3 levels from disregulation of PI3-K have been demonstrated in cancer and inflammatory diseases. PIP3 is hydrolyzed by the phosphatases PTEN to PI(4, 5)P2 and SHIP to PI(3, 4)P2. Storage 2-8 °C for up to 30 days, -20 °C for greater than 30 days. Do not freeze thaw multiple times. Featured in Publications 1) Sweeney, G., R. R. Garg, et al. (2004). "Intracellular delivery of phosphatidylinositol (3, 4, 5)-trisphosphate causes incorporation of glucose transporter 4 into the plasma membrane of muscle and fat cells without increasing glucose uptake." J Biol Chem 279(31): 32233-42. 2) Papakonstanti, E. A., A. J. Ridley, et al. (2007). "The p110delta isoform of PI 3-kinase negatively controls RhoA and PTEN." Embo J 26(13): 3050-61. 3) Maffucci, T., C. Raimondi, et al. (2009). "A phosphoinositide 3-kinase/phospholipase Cgamma1 pathway regulates fibroblast growth factor-induced capillary tube formation." PLoS One 4(12): e8285. 4) Wang, Y., L. M. Weiss, et al. (2010). "Coordinate control of host centrosome position, organelle distribution, and migratory response by Toxoplasma gondii via host mTORC2." J Biol Chem 285(20): 15611-8. |
| Order #: | ECH-Z-P345B-250UG |
| Unit Size: | 250 ug |
| Supplier: | Echelon Biosciences |
| Restrictions: | Available in all European countries, except France & Italy. |
| Shipping: | Dry Ice |
| Storage: | -20 °C or below |
| Subcategory: | Antibodies & Proteins |
| More information: | Go to webpage |
2,082.00 € *
*All prices are net in Euro and do not include applicable taxes, shipping & handling, or other charges (e.g., customs duties).
Delivery time approx. 8 - 10 working days
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