Resveratrol (Echelon Product Code: B-0021 50MG)
| Description: | Resveratrol is a class IA PI3K inhibitor, activates SIRT1, and displays antiproliferative effect on human breast epithelial cells. By depolarization of mitochondrial membrane and caspase-9 activation resveratrol induces apoptosis. In addition, Resveratrol inhibits ribonucleotide reductase and DNA synthesis, cyclooxygenase-1, PKD, and eicosanoid synthesis. » References 1) S Fröjdö, (et al.) Resveratrol is a class IA phosphoinositide 3-kinase inhibitor( Biochem J.) 406 511 (2007) 2) K.T. Howitz (et al. )Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan.( Nature) 425 191 (2003) 3) O.P. Mgbonyebi (et al. )Antiproliferative effect of synthetic resveratrol on human breast epithelial cells.( Int. J. Oncol. )12 865 (1998) 3) J. Dorrie (et al. )Resveratrol induces extensive apoptosis by depolarizing mitochondrial membranes and activating caspase-9 in acute lymphoblastic leukemia cells. (Cancer Res. )61 4731 (2001) 4) M. Fontecave (et al.) Resveratrol, a remarkable inhibitor of ribonucleotide reductase.( FEBS Lett. )421 277 (1998) 5) M. Jang, (et al.) Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. (Science) 275 218-220 (1997) 6) J.R. Stewart (et al. )Effects of resveratrol on the autophosphorylation of phorbol ester-responsive protein kinases: inhibition of protein kinase D but not protein kinase C isozyme autophosphorylation.( Biochem. Pharmacol. )60 1355 (2000) |
| Order #: | ECH-B-0021-50MG |
| Unit Size: | 50 mg |
| Supplier: | Echelon Biosciences |
| Restrictions: | Available in all European countries, except France & Italy. |
| Shipping: | Room Temperature |
| Storage: | -20 °C or below |
| Subcategory: | Biochemical Reagents |
| More information: | Go to webpage |
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