1R, 2R-B13 (Ceramidase inhibitor) (Echelon Product Code: B-0042 5MG)
| Description: | Ceramides are bioactive sphingolipids which induce apoptosis in cells. Ceramidases, which hydrolyze the fatty acid chain, keep ceramide levels in check and have been proposed as a target for small-molecule inhibitors for anti-cancer therapy. B13 (or D-NMAPPD) is a potent ceramidase inhibitor which causes aopotosis in a number of cell lines including colorectal, HL60, melanoma, and keratinocyes. » References 1) A. Bielawska, C.M. Linardic, Y. Hannun "Ceramide-mediated biology. Determination of structural and stereospecific requirements through the use of N-acyl-phenylaminoalcohol analogs" J. Biol. Chem., 1992, 267, 18493-7. 2) M. Raisova, G. Goltz, et al. "Bcl-2 overexpression prevents apoptosis induced by ceramidase inhibitors in malignant melanoma and HaCaT keratinocytes" FEBS Letters 2002, 516, 47-52. 3) Bhabak, Krishna P. Kleuser, Burkhard "Effective inhibition of acid and neutral ceramidases by novel B-13 and LCL-464 analogues" Bioorganic & Medicinal Chemistry 2013, 21, 874-882. |
| Order #: | ECH-B-0042-5MG |
| Unit Size: | 5 mg |
| Supplier: | Echelon Biosciences |
| Restrictions: | Available in all European countries, except France & Italy. |
| Shipping: | Room Temperature |
| Storage: | -20 °C or below |
| Subcategory: | Biochemical Reagents |
| More information: | Go to webpage |
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