FPA-124 (Akt Inhibitor) (Echelon Product Code: B-0101 5MG)
| Description: | FPA-124 is a cell-permeable inhibitor of Akt (IC(50) = 100 nM), binding to the PH and kinase domains. It inhibits cell proliferation in Colo357, BxPC3, BT20, and PC3 cancer cell lines with IC(50) values ranging from 7-55 nM. FPA-124 inhibited tumor growth in mice with negligible toxicity. » References 1) V. Barve, et al. "Synthesis, Molecular Characterization, and Biological Activity of Novel Synthetic Derivatives of Chromen-4-one in Human Cancer Cells" J. Med. Chem., 2006, 49, 3800-3808. 2) Biscetti, F., G. Straface, et al. (2009). "Pioglitazone enhances collateral blood flow in ischemic hindlimb of diabetic mice through an Akt-dependent VEGF-mediated mechanism, regardless of PPARgamma stimulation." Cardiovasc Diabetol 8: 49. 3) Brito, P. M., R. l. Devillard, et al. (2009). "Resveratrol inhibits the mTOR mitogenic signaling evoked by oxidized LDL in smooth muscle cells." Atherosclerosis 205(1): 126. |
| Order #: | ECH-B-0101-5MG |
| Unit Size: | 5 mg |
| Supplier: | Echelon Biosciences |
| Restrictions: | Available in all European countries, except France & Italy. |
| Shipping: | Room Temperature |
| Storage: | 4-8 °C |
| Subcategory: | Biochemical Reagents |
| More information: | Go to webpage |
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