LY294002 (PI3-K Inhibitor) (Echelon Product Code: B-0294 5MG)
| Description: | LY294002 is a selective, cell permeable, potent and specific inhibitor of phosphatidylinositol 3-kinase (IC(50) = 1.4 µM; purified PI 3-kinase). It does not significantly inhibit PKC, PKA, MAP kinase, S6 kinase, EGFrK, c-src kinase, PI 4-kinase, DAG kinase or rabbit kidney ATPase at concentrations of 50 µM. Induces apoptosis. In intact neutrophils stimulated with fMet-Leu-Phe, LY294002 completely abolished PI 3-kinase activity at 50 µM without cell toxicity. 1. Coronas-Serna JM, Fern ndez-Acero T, Molina M, Cid VJ. A humanized yeast-based toolkit for monitoring phosphatidylinositol 3-kinase activity at both single cell and population levels. Microbial Cell. 2018;5(12):545-54. 2. Chang P, Walker MC, Williams RS. Seizure-induced reduction in PIP3 levels contributes to seizure-activity and is rescued by valproic acid. Neurobiol Dis. 2014;62:296-306. 3. Fern ndez-Acero T, RodrÇguez-Escudero I, Vicente F, Monteiro MCn, Tormo JR, Cantizani J, et al. A Yeast-Based In Vivo Bioassay to Screen for Class I Phosphatidylinositol 3-Kinase Specific Inhibitors. Journal of Biomolecular Screening. 2012;17(8):1018-29. |
| Order #: | ECH-B-0294-5MG |
| Unit Size: | 5 mg |
| Supplier: | Echelon Biosciences |
| Restrictions: | Available in all European countries, except France & Italy. |
| Shipping: | Room Temperature |
| Storage: | 4-8 °C |
| Subcategory: | Biochemical Reagents |
| More information: | Go to webpage |
68.00 € *
*All prices are net in Euro and do not include applicable taxes, shipping & handling, or other charges (e.g., customs duties).
Delivery time approx. 8 - 10 working days
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