AS605240 (PI3-K gamma Inhibitor 1) (Echelon Product Code: B-0301 1MG)
| Description: | 5-quinoxilin-6-methylene-1, 3-thiazolidine-2, 4-dione (AS605240) is an ATP-competitive inhibitor of PI3-K" (IC(50) = 8 nM). It is selective for the "-isoform (IC(50): PI 3-K" = 60 nM, PI 3-K" = 270 nM, PI 3-K" = 300 nM) and shows no notable activity against a wide array of protein kinases at 1 µM. In addition, AS605240 suppresses the progression of joint inflammation in a mouse model of rheumatoid arthritis and suppresses inflammation in a mouse model of lupus. » References; 1) M. Camps et al. "Blockade of PI3Kg suppresses joint inflammation and damage in mouse models of rheumatoid arthritis" Nature Medicine, 2005, 11, 936-943. 2) D.F. Barber, et al., PI3Kg inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus" Nature Medicine, 2005, 11, 933-935. |
| Order #: | ECH-B-0301-1MG |
| Unit Size: | 1 mg |
| Supplier: | Echelon Biosciences |
| Restrictions: | Available in all European countries, except France & Italy. |
| Shipping: | Room Temperature |
| Storage: | 4-8 °C |
| Subcategory: | Biochemical Reagents |
| More information: | Go to webpage |
Add to request list
- Phone: +49 (0)89 3799666-6
- E-mail: info@biozol.de
MoBiTec is now part of BIOZOL
All orders and requests placed via the online shop on www.mobitec.com are processed by BIOZOL Diagnostica Vertrieb GmbH.
You will receive an order confirmation by fax or e-mail. More information regarding the ordering process can be found here.
Technical Service - Product Information
Viewed