AS605240 (PI3-K gamma Inhibitor 1) (Echelon Product Code: B-0301 5MG)
| Description: | 5-quinoxilin-6-methylene-1, 3-thiazolidine-2, 4-dione (AS605240) is an ATP-competitive inhibitor of PI3-K" (IC(50) = 8 nM). It is selective for the "-isoform (IC(50): PI 3-K" = 60 nM, PI 3-K" = 270 nM, PI 3-K" = 300 nM) and shows no notable activity against a wide array of protein kinases at 1 µM. In addition, AS605240 suppresses the progression of joint inflammation in a mouse model of rheumatoid arthritis and suppresses inflammation in a mouse model of lupus. » References; 1) M. Camps et al. "Blockade of PI3Kg suppresses joint inflammation and damage in mouse models of rheumatoid arthritis" Nature Medicine, 2005, 11, 936-943. 2) D.F. Barber, et al., PI3Kg inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus" Nature Medicine, 2005, 11, 933-935. |
| Order #: | ECH-B-0301-5MG |
| Unit Size: | 5 mg |
| Supplier: | Echelon Biosciences |
| Restrictions: | Available in all European countries, except France & Italy. |
| Shipping: | Room Temperature |
| Storage: | 4-8 °C |
| Subcategory: | Biochemical Reagents |
| More information: | Go to webpage |
110.00 € *
*All prices are net in Euro and do not include applicable taxes, shipping & handling, or other charges (e.g., customs duties).
Delivery time approx. 8 - 10 working days
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