PI-103 (PI3-K alpha Inhibitor 1) (Echelon Product Code: B-0303 5MG)
| Description: | PI-103 is a selective inhibitor for the "-isoform of PI 3-Kinase (IC50: PI 3-Kα = 8 nM, PI 3-Kβ = 88 nM, PI 3-Kδ = 48 nM, PI 3-Kγ = 150 nM). It is also inhibits DNA-PK (IC(50) = 2 nM) and mTOR1 and mTOR2 (IC(50) = 20 & 83 nM). PI-103 shows little activity against a wide array of protein kinases at 10µM. PI-103 blocks glioma proliferation by blocking the PI 3-K/Akt pathway (in vitro) and (in vivo). » References; 1) Fan, Q., et al. (2006) ."A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma." Cancer Cell 9: 341-349. 2) Smit, M. A., T. R. Geiger, et al. (2009). "A Twist-Snail axis critical for TrkB-induced epithelial-mesenchymal transition-like transformation, anoikis resistance, and metastasis." Mol Cell Biol 29(13): 3722-37. 3) Gursel, D. B., Y. S. Connell-Albert, et al. (2011). "Control of proliferation in astrocytoma cells by the receptor tyrosine kinase/PI3K/AKT signaling axis and the use of PI-103 and TCN as potential anti-astrocytoma therapies." Neuro-Oncology 13(6): 610-621. |
| Order #: | ECH-B-0303-5MG |
| Unit Size: | 5 mg |
| Supplier: | Echelon Biosciences |
| Restrictions: | Available in all European countries, except France & Italy. |
| Shipping: | Room Temperature |
| Storage: | -20 °C or below |
| Subcategory: | Biochemical Reagents |
| More information: | Go to webpage |
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