Apilimod (PIKfyve inhibitor) (Echelon Product Code: B-0308 25MG)
| Description: | Background Apilimod inhibits the kinase PIKfyve which phosphorylates PI(3)P to PI(3, 5)P2 with an IC50 = 14 nM. PIKfyve has an important role in endosome formation and related pathways. Apilimod also inhibits Interleukin-12 (IL-12) and Interleukin-23 (IL-23) at 1-2 nM levels in cells. Apilimod has recently been shown to inhibit SARS-Cov2 replication in iPSC-derived pneumocyte-like cells and a primary human lung explant model. Apilimod is orally bioavailable and cell-permeable. » References 1) Y. Wada, et al. "Selective abrogation of Th1 response by STA-5326, a potent IL-12/IL-23 inhibitor" Blood, (2007) 109(3), 1156-1164 doi: 10.1182/blood-2006-04-019398. 2) S. Gayle, et al. "Identification of apilimod as a first-in-class PIKfyve kinase inhibitor for treatment of B-cell non-Hodgkin lymphoma" (2017) 129 (13): 1768"1778. DOI: 10.1182/blood-2016-09-736892. 3) L. Riva et al. " Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing" Nature (2020); https://doi.org/10.1038/s41586-020-2577-1 |
| Order #: | ECH-B-0308-25MG |
| Unit Size: | 25 mg |
| Supplier: | Echelon Biosciences |
| Restrictions: | Available in all European countries, except France & Italy. |
| Shipping: | Room Temperature |
| Storage: | -20 °C or below |
| Subcategory: | Biochemical Reagents |
| More information: | Go to webpage |
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