K149 (SHIP2 Inhibitor) (Echelon Product Code: B-0345 10MG)
| Description: | SH2-Domain containing inositol 5-phosphatases (SHIP1 & SHIP2) dephosphorylate the 5-position of PI(3, 4, 5)P3 generating PI(3, 4)P2. PI(3, 4)P2 activates Protein Kinase B (PKB/Akt) and promotes cell survival. SHIP2 expression and activity is increased in colorectal cancer suggesting an oncogenic role. Treatment of colorectal cancer cells with K149 (2uM) decreases PKB/Akt signaling and sensitizes the cells to 5-fluorouracil regardless of whether the cell lines have a PI3KCA mutation. » References 1) E. Hoekstra, A.H. Das, et al. "Lipid phosphatase SHIP2 functions as oncogene in colorectal cancer by regulating PKB activation" Oncotarget 2016; 7:73525-73540. DOI: 10.18632/oncotarget.12321; |
| Order #: | ECH-B-0345-10MG |
| Unit Size: | 10 mg |
| Supplier: | Echelon Biosciences |
| Restrictions: | Available in all European countries, except France & Italy. |
| Shipping: | Room Temperature |
| Storage: | -20 °C or below |
| Subcategory: | Biochemical Reagents |
| More information: | Go to webpage |
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