VO-OHpic (PTEN Inhibitor) (Echelon Product Code: B-0351 10MG)
| Description: | The vanadium complex VO-OHpic is a potent, reversible, allosteric inhibitor of phosphatase and tensin homologue deleted on chromosome 10 (PTEN) which hydrolyzes the 3-phosphate from phosphatidylinositol 3, 4, 5-trisphosphate (PIP3). PIP3, formed from PI(4, 5)P2 though phosphorylation by PI 3-kinase, activates numerous signaling pathways resulting in cell proliferation, growth, survival, glucose transport and protein synthesis. VO-OHpic is reported to be selective for PTEN (IC(50)~35 nM) compared with other cysteine-based phosphatases (PTP", SAC, MTM, & SopB, IC(50) 4 µM). Treatment of insulin-stimulated NIH 3T3 and L1 fibroblasts caused an increase in Akt-phosphorylation indicating inhibition of PTEN in vivo. |
| Order #: | ECH-B-0351-10MG |
| Unit Size: | 10 mg |
| Supplier: | Echelon Biosciences |
| Restrictions: | Available in all European countries, except France & Italy. |
| Shipping: | Room Temperature |
| Storage: | -20 °C or below |
| Subcategory: | Biochemical Reagents |
| More information: | Go to webpage |
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