7-azido-4-methylcoumarin (AzMC, Hydrogen sulfide detector) (Echelon Product Code: D-0010 1MG)
| Description: | This novel and selective probe for hydrogen sulfide (H(2)S), 7-azido-4-methylcoumarin (AzMC), is useful for monitoring cystathionine B-synthase (CBS) catalyzed reactions, which play a critical role in human sulfur metabolism. Deactivated CBS is characterized by high plasma levels of homocysteine and H2S, resulting in clinical manifestations of numerous disease states. AzMC, used as a fluorgenic probe and concurrent CBS activity, can be used to select compounds for activation or inhibition of this enzyme, and is suitable for high-throughput screening and the development of potential therapeutics. In addition, AzMC has been used as a photoaffinitry probe for the substrate binding site of human phenol sulfotransferase (SULT1A-1 or P-PST-1). Featured in » References 1. M.K. Thorson, T. Majtan, J.P. Kraus, A.M. Barrios "Identification of Cystathionine "-Synthase Inhibitors Using a Hydrogen Sulfide Selective Probe." Angewandte Chemie (Int. ed. Eng.) 2013, 52, 4641-4144. DOI: 10.1002/anie.201300841; 2. G. Chen, et al. "Photoaffinity labeling probe for the substrate binding site of human phenol sulfotransferase (SULT1A1): 7-azido-4-methylcoumarin." Protein Sci., 1999, 8, 2151-2157, doi:10.1110/ps.8.10.2151; 3. Q-L Xie, et a. "An azidocoumarin-based fluorescent probe for imaging lysosomal hydrogen sulfide in living cells" Analytical Methods, 2017, DOI: 10.1039/C7AY00862G; |
| Order #: | ECH-D-0010-1MG |
| Unit Size: | 1 mg |
| Supplier: | Echelon Biosciences |
| Restrictions: | Available in all European countries, except France & Italy. |
| Shipping: | Room Temperature |
| Storage: | -20 °C or below |
| Subcategory: | Biochemical Reagents |
| More information: | Go to webpage |
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