1-Deoxy-D-xylulose 5-phosphate (DXP) (Echelon Product Code: I-M050 5MG)
| Description: | Isoprenoid compounds are a diverse group of natural products which are essential components in all cells. Isoprenoids are biosynthesized from the simple precursors isopentenyl diphosphate (IPP); and dimethylallyl diphosphate (DMAPP). Eukaryotes, fungi, and some gram-positive bacteria produce IPP through the mevalonate (MVA) pathway whereas gram-negative and some gram-positive bacteria utilize the non-mevalonate or 2-C-methyl-D-erythritol-4-phosphate (MEP); pathway. 1-Deoxy-D-xylulose 5-phosphate (DXP) is an intermediate in the non-mevalonate pathway and is formed from pyruvate and glyceraldehyde 3-phosphate by DXP synthase. It is converted to MEP by MEP Synthase (DXP reductoisomerase). Provided as the sodium salt Alternate Names: 1-Deoxy-D-xylulose 5-phosphate, 1-Deoxyxylulose 5-phosphate, Deoxyxylulose phosphate, DOXP, DXP ;;; 1) Poliquin, K., Y. V. Ershov, et al. (2004). "Inactivation of sll1556 in Synechocystis Strain PCC 6803 Impairs Isoprenoid Biosynthesis from Pentose Phosphate Cycle Substrates In Vitro." J Bacteriol 186(14): 4685-4693. 2) Gottlin, E. B., R. E. Benson, et al. (2003). "High-throughput screen for inhibitors of 1-deoxy-d-xylulose 5-phosphate reductoisomerase by surrogate ligand competition." J Biomol Screen 8(3): 332-9. 3) Bailey, A. M., S. Mahapatra, et al. (2002). "Identification, cloning, purification, and enzymatic characterization of Mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate synthase." Glycobiology 12(12): 813-20. 4) Zhou, K., et al. (2012). µMetabolite Profiling Identified Methylerythritol Cyclodiphosphate Efflux as a Limiting Step in Microbial Isoprenoid Production." PLoS ONE 7(11): e47513. 5) Haymond, A., et al. (2014). "Kinetic Characterization and Allosteric Inhibition of the Yersinia pestis 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase (MEP Synthase)." PLoS ONE 9(8): e106243. 6) Parkinson, E. I., et al. (2019). "Fosmidomycin biosynthesis diverges from related phosphonate natural products." Nat Chem Biol 15: 1049-1056. |
| Order #: | ECH-I-M050-5MG |
| Unit Size: | 5 mg |
| Supplier: | Echelon Biosciences |
| Restrictions: | Available in all European countries, except France & Italy. |
| Shipping: | Gel Ice |
| Storage: | -20 °C or below |
| Subcategory: | Biochemical Reagents |
| More information: | Go to webpage |
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