2-C-Methyl-D-erythritol 2, 4-cyclophosphate (cMEPP) (Echelon Product Code: I-M054 1MG)
| Description: | Isoprenoid compounds are a diverse group of natural products which are essential components in all cells. Isoprenoids are biosynthesized from the simple precursors isopentenyl diphosphate (IPP); and dimethylallyl diphosphate (DMAPP). Eukaryotes, fungi, and some gram-positive bacteria produce IPP through the mevalonate (MVA) pathway whereas gram-negative and some gram-positive bacteria utilize the non-mevalonate or 2-C-methyl-D-erythritol-4-phosphate (MEP); pathway. 2-C-Methyl-D-erythritol 2, 4-cyclophosphate (cMEPP) is an intermediate in the non-mevalonate pathway. It is formed by from MECDP Synthase from CDP-MEP and converted to 1-hydroxy-2-methyl-2-buten-4-yl diphosphate (HDMAPP) by IspG (GcpE). Featured in Publications 1) Xiao, Y., T. Savchenko, et al. (2012). "Retrograde Signaling by the Plastidial Metabolite MEcPP Regulates Expression of Nuclear Stress-Response Genes." Cell 149(7): 1525. 2) Zhou, K., R. Zou, et al. (2012). µMetabolite Profiling Identified Methylerythritol Cyclodiphosphate Efflux as a Limiting Step in Microbial Isoprenoid Production." PLoS ONE 7(11): e47513. 3) Hsiao, C.-H. C. and A. J. Wiemer (2018). "A power law function describes the time- and dose-dependency of V"9V"2 T cell activation by phosphoantigens." Biochem Pharmacol 158: 298-304. 4) Ma, Y., et al. (2019). µMetabolic Engineering of the MEP Pathway in Bacillus subtilis for Increased Biosynthesis of Menaquinone-7." ACS Synthetic Biology 8(7): 1620-1630. Alternate Names:cMEPP, MEcPP |
| Order #: | ECH-I-M054-1MG |
| Unit Size: | 1 mg |
| Supplier: | Echelon Biosciences |
| Restrictions: | Available in all European countries, except France & Italy. |
| Shipping: | Gel Ice |
| Storage: | -20 °C or below |
| Subcategory: | Biochemical Reagents |
| More information: | Go to webpage |
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